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Modeling the effect of red blood cells deformability on blood flow conditions in human carotid artery bifurcation
ID
Urevc, Janez
(
Avtor
),
ID
Žun, Iztok
(
Avtor
),
ID
Brumen, Milan
(
Avtor
),
ID
Štok, Boris
(
Avtor
)
PDF - Predstavitvena datoteka,
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MD5: 7E4F9EF00B1F5EAF90D1DC505D043E08
URL - Izvorni URL, za dostop obiščite
https://asmedigitalcollection.asme.org/biomechanical/article-abstract/139/1/011011/371365/Modeling-the-Effect-of-Red-Blood-Cells?redirectedFrom=fulltext
Galerija slik
Izvleček
The purpose of this work is to predict the effect of impaired red blood cells (RBCs) deformability on blood flow conditions in human carotid artery bifurcation. First, a blood viscosity model is developed that predicts the steady-state blood viscosity as a function of shear rate, plasma viscosity, and mechanical (and geometrical) properties of RBC's. Viscosity model is developed by modifying the well-known Krieger and Dougherty equation for monodisperse suspensions by using the dimensional analysis approach. With the approach, we manage to account for the microscopic properties of RBC's, such as their deformability, in the macroscopic behavior of blood via blood viscosity. In the second part of the paper, the deduced viscosity model is used to numerically predict blood flow conditions in human carotid artery bifurcation. Simulations are performed for different values of RBC's deformability and analyzed by investigating parameters, such as the temporal mean wall shear stress (WSS), oscillatory shear index (OSI), and mean temporal gradient of WSS. The analyses show that the decrease of RBC's deformability decrease the regions of low WSS (i.e., sites known to be prevalent at atherosclerosis-prone regions); increase, in average, the value of WSS along the artery; and decrease the areas of high OSI. These observations provide an insight into the influence of blood's microscopic properties, such as the deformability of RBC's, on hemodynamics in larger arteries and their influence on parameters that are known to play a role in the initiation and progression of atherosclerosis.
Jezik:
Angleški jezik
Ključne besede:
blood viscosity model
,
non-Newtonian fluids
,
blood flow
,
computational fluid dynamics
,
biomechanics
,
bifurcation
,
blood
,
carotid arteries
,
hemorheology
,
modeling
,
shear rate
,
viscosity
,
flow
,
dynamics
,
hemodynamics
,
particulate matter
,
shear stress
,
erythrocytes
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FS - Fakulteta za strojništvo
Status publikacije:
Objavljeno
Različica publikacije:
Recenzirani rokopis
Leto izida:
2017
Št. strani:
11 str.
Številčenje:
Vol. 139, iss. 1, art. 011011
PID:
20.500.12556/RUL-160784-6746e440-d809-7c69-0ddf-695251a79579
UDK:
532:616.13(045)
ISSN pri članku:
0148-0731
DOI:
10.1115/1.4035122
COBISS.SI-ID:
15115291
Datum objave v RUL:
04.09.2024
Število ogledov:
91
Število prenosov:
34
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Objavi na:
Gradivo je del revije
Naslov:
Journal of biomechanical engineering
Skrajšan naslov:
J. biomech. eng.
Založnik:
American Society of Mechanical Engineers
ISSN:
0148-0731
COBISS.SI-ID:
6758149
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
model viskoznosti krvi
,
tok krvi
,
nenewtonske tekočine
,
računalniška dinamika tekočin
,
mehanika tekočin
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P2-0162
Naslov:
Tranzientni dvofazni tokovi
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
L3-2319
Naslov:
Morfološke spremembe notranje karotidne arterije po vstavitvi žilne opornice
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