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Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes : a contribution to the understanding of the systemic toxicity of cyanotoxins
ID
Bubik, Anja
(
Avtor
),
ID
Frangež, Robert
(
Avtor
),
ID
Žužek, Monika C.
(
Avtor
),
ID
Gutiérrez-Aguirre, Ion
(
Avtor
),
ID
Lah Turnšek, Tamara
(
Avtor
),
ID
Sedmak, Bojan
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(12,40 MB)
MD5: F06BDF9A81CF5D83FDA1F35E2BFF4285
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2072-6651/16/9/374
Galerija slik
Izvleček
The systemic toxicity of cyclic peptides produced by cyanobacteria (CCPs) is not yet completely understood. Apart from the most known damages to the liver and kidneys, symptoms of their neurotoxicity have also been reported. Hepatotoxic CCPs, like microcystins, as well as non-hepatotoxic anabaenopeptins and planktopeptins, all exhibit cytotoxic and cytostatic effects on mammalian cells. However, responses of different cell types to CCPs depend on their specific modes of interaction with cell membranes. This study demonstrates that non-hepatotoxic planktopeptin BL1125 and anabaenopeptins B and F, at concentrations up to 10 µM, affect normal and tumor human astrocytes (NHA and U87-GM) in vitro by their almost immediate insertion into the lipid monolayer. Like microcystin-LR (up to 1 µM), they inhibit Ser/Thr phosphatases and reorganize cytoskeletal elements, with modest effects on their gene expression. Based on the observed effects on intermediate filaments and intermediate filament linkage elements, their direct or indirect influence on tubulin cytoskeletons via post-translational modifications, we conclude that the basic mechanism of CCP toxicities is the induction of inter- and intracellular communication failure. The assessed inhibitory activity on Ser/Thr phosphatases is also crucial since the signal transduction cascades are modulated by phosphorylation/dephosphorylation processes.
Jezik:
Angleški jezik
Ključne besede:
astrocytes
,
cyclic cyanobacterial peptides
,
cytoskeletal organization
,
Ser/Thr phosphatases
,
systemic toxicity
,
peptides
,
cyanobacteria toxins
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
18 str.
Številčenje:
Vol. 16, iss. 9, art. 374
PID:
20.500.12556/RUL-160378
UDK:
576:616-092
ISSN pri članku:
2072-6651
DOI:
10.3390/toxins16090374
COBISS.SI-ID:
205320707
Datum objave v RUL:
27.08.2024
Število ogledov:
53
Število prenosov:
16
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Objavi na:
Gradivo je del revije
Naslov:
Toxins. Elektronski vir
Skrajšan naslov:
Toxins
Založnik:
MDPI
ISSN:
2072-6651
COBISS.SI-ID:
517594649
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
27.08.2024
Projekti
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
J1-0848
Naslov:
Antikancerogeno delovanje bioaktivnih spojin cianobakterijskega izvora v nasprotju možganskih tumorjev - gliobastomov
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P4-0053
Naslov:
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Ministry of Defence, Administration for Civil Protection and Disaster Relief
Številka projekta:
URSZR 4300-1117/2009/1
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