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Reference intervals of 24 trace elements in blood, plasma and erythrocytes for the Slovenian adult population
ID
France Štiglic, Alenka
(
Avtor
),
ID
Falnoga, Ingrid
(
Avtor
),
ID
Sešek-Briški, Alenka
(
Avtor
),
ID
Žavbi, Marko
(
Avtor
),
ID
Osredkar, Joško
(
Avtor
),
ID
Skitek, Milan
(
Avtor
),
ID
Marc, Janja
(
Avtor
)
PDF - Predstavitvena datoteka,
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MD5: 39958F4A821A05788A7B180254F83FF2
URL - Izvorni URL, za dostop obiščite
https://www.degruyter.com/document/doi/10.1515/cclm-2023-0731/html
Galerija slik
Izvleček
Objectives: The aim of the present study was to establish the population- and laboratory-specific reference intervals (RIs) for the Slovenian adult population for 24 trace elements (TEs) in blood, plasma and erythrocytes and to evaluate the impact of gender, age, seafood consumption, smoking habits and amalgam fillings on TEs levels. Methods: TEs (Mn, Co, Cu, Zn, Se and Mo, Li, Be, V, Cr, Ni, Ga, As, Rb, Sr, Ag, Cd, Sn, Cs, Au, Hg, Tl, Pb and U) were determined in 192 a priori selected blood donors (107 women and 85 men, aged 18–65 years), using inductively coupled plasma mass spectrometry (ICP-MS) with the Octopole Reaction System. Participants filled out a questionnaire, and RIs were established according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for TEs. Results: Uniform RIs for non-essential and gender-specific for essential TEs in blood, plasma and erythrocytes were established. In our population, higher blood and plasma Cu, and erythrocyte Mn levels in women were found. In men, blood Zn, plasma Zn, Mn and Se, and erythrocyte Cu levels were higher. Zn levels were higher in 30–39 years age group. Pb and Sr increased with age. Smoking positively affected Cd, Pb, Cs and Rb; seafood consumption increased As, Hg and Zn; and amalgam increased Hg, Ag and Cu levels. Conclusions: Essential TEs were inside recommended levels, and the non-essential ones were far below critical levels. Established RIs will provide an important foundation for clinical diagnostics, safety erythrocyte transfusions assessment, toxicology and epidemiological studies.
Jezik:
Angleški jezik
Ključne besede:
amalgam fillings
,
essential trace elements
,
non-essential trace elements
,
gender
,
inductively coupled plasma mass spectroscopy
,
ICP-MS
,
seafood
,
smoking
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
Str. 946–957
Številčenje:
Vol. 62, iss. 5
PID:
20.500.12556/RUL-160104
UDK:
616-074
ISSN pri članku:
1437-4331
DOI:
10.1515/cclm-2023-0731
COBISS.SI-ID:
173784835
Datum objave v RUL:
20.08.2024
Število ogledov:
18
Število prenosov:
6
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Objavi na:
Gradivo je del revije
Naslov:
Clinical chemistry and laboratory medicine
Skrajšan naslov:
Clin. chem. lab. med.
Založnik:
De Gruyter, European Federation of Clinical Chemistry and Laboratory Medicine
ISSN:
1437-4331
COBISS.SI-ID:
680355
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
amalgamske zalivke
,
esencialni elementi v sledovih
,
nebistveni elementi v sledovih
,
spol
,
masna spektroskopija z induktivno sklopljeno plazmo
,
ICP-MS
,
morski sadeži
,
kajenje
,
klinična kemija
,
diagnostika
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