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Canine ovarian epithelial tumours : histopathological and immunohistochemical evaluation with proposed histopathological classification system
ID Dolenšek, Tamara (Avtor), ID Knific, Tanja (Avtor), ID Ramírez, Gustavo A. (Avtor), ID Erles, Kerstin (Avtor), ID Mallon, Hannah E. (Avtor), ID Priestnall, Simon L. (Avtor), ID Suárez-Bonnet, Alejandro (Avtor)

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Izvleček
Canine ovarian epithelial tumours (OETs) are currently divided into ovarian adenomas and carcinomas, which are further inconsistently subclassified as papillary or cystic, whereas in human medicine, OETs are subdivided into several subtypes. This study aimed to establish clear morphological features enabling more consistent distinction between benign OETs and ovarian carcinomas (OvCas) as well as defining different histopathological patterns of canine OvCas. Analysis revealed a mitotic count threshold of >2 as a potential criterion for differentiating OvCas from benign OETs. Alongside ovarian adenomas, ovarian borderline tumours were introduced as a distinct category among benign OETs. OvCas exhibited five different histopathological patterns, namely papillary, solid with tubular differentiation, micropapillary, cystic and sarcomatous. Since some OvCas can morphologically overlap with other ovarian tumours, the expression of cytokeratin 7, a cytokeratin expressed in ovarian epithelium, was assessed and proved helpful, although it was not expressed in all cases. Furthermore, we investigated the expression of 14-3-3σ and cyclooxygenase 2 (COX-2). Based on the frequent expression of 14-3-3σ, this marker appears to have a role in canine OETs since it is not expressed in normal canine ovaries. The infrequent expression of COX-2 suggests that it is a poor candidate as a potential therapeutic target in canine OvCas.

Jezik:Angleški jezik
Ključne besede:14-3-3σ protein, canine, CK7, COX-2, ovarian carcinoma, ovarian epithelial tumour, tumour classification, pathology, neoplasms, dogs
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:Str. 42-50
Številčenje:Vol. 212
PID:20.500.12556/RUL-159800 Povezava se odpre v novem oknu
UDK:636.09:616
ISSN pri članku:1532-3129
DOI:10.1016/j.jcpa.2024.05.006 Povezava se odpre v novem oknu
COBISS.SI-ID:201195267 Povezava se odpre v novem oknu
Datum objave v RUL:25.07.2024
Število ogledov:230
Število prenosov:42
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Journal of comparative pathology
Skrajšan naslov:J. comp. pathol.
Založnik:Elsevier
ISSN:1532-3129
COBISS.SI-ID:158982403 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:University of London, Royal Veterinary College, Postgraduate School, Master of Veterinary Medicine

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