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Real-world data on the Minimed 780G advanced hybrid closed-loop system use during type 1 diabetes pregnancy : one centre observational study
ID Munda, Ana (Avtor), ID Kovacic, Chiara (Avtor), ID Pongrac Barlovič, Draženka (Avtor)

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Izvleček
Aim: The efficacy of hybrid closed-loop systems (HCLs) in managing glycemic control in pregnant women with type 1 diabetes remains inadequately characterized. We evaluated the use of the Medtronic Minimed 780G HCLs. Methods: The retrospective observational study analyzed the glycemic and perinatal outcomes of pregnant women using the HCLs, followed at our tertiary centre. Independent t-tests were employed to compare data among trimesters based on pre-pregnancy HbA$_{1c}$. The associations between glycemic parameters and perinatal outcomes were explored using Spearman rho. Results: Among the 21 women (age: 33.5 ± 4.2 years, diabetes duration: 21.2 ± 7.6 years, pre-pregnancy HbA$_{1c}$ 7.0 ± 1.1 % (52.9 ± 11.9 mmol/mol)) time in range (pTIR, 63–140 mg/dl; 3.5–7.8 mmol/l) increased progressively throughout pregnancy (trimesters: first: 64.0 ± 9.0 %; second:71.3 ± 11.8 %; third: 75.7 ± 8.1 %). Simultaneously, mean sensor glucose decreased (trimesters: first: 130 ± 10.4 mg/dl (7.2 ± 0.6 mmol/l); second: 120.9 ± 13.4 mg/dl (6.7 ± 0.7 mmol/l); third: 117.3 ± 9.1 mg/dl (6.5 ± 0.5 mmol/l)). Although a majority of women achieved the target pTIR until the third trimester, this did not consistently prevent the delivery of a largefor-gestational-age baby. Notably, one ketoacidosis event occurred, and there were no reported instances of severe hypoglycemia. Conclusion: Use of the Minimed 780G HCLs enabled the attainment of recommended pregnancy glycemic targets for most women with type 1 diabetes in a real-world setting.

Jezik:Angleški jezik
Ključne besede:type 1 diabetes, pregnancy, continuous glucose monitoring, closed-loop insulin delivery, automated insulin delivery, time in range, pregnancy outcomes
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:7 str.
Številčenje:Vol. 38, iss. 8, art. 108795
PID:20.500.12556/RUL-159398 Povezava se odpre v novem oknu
UDK:616.379
ISSN pri članku:1873-460X
DOI:10.1016/j.jdiacomp.2024.108795 Povezava se odpre v novem oknu
COBISS.SI-ID:200991491 Povezava se odpre v novem oknu
Datum objave v RUL:09.07.2024
Število ogledov:98
Število prenosov:19
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Journal of diabetes and its complications
Založnik:Elsevier
ISSN:1873-460X
COBISS.SI-ID:518773785 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:University Medical Centre Ljubljana
Številka projekta:20220126

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