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Hemogram-derived inflammatory markers in cats with chronic kidney disease
ID
Krofič, Martina
(
Avtor
),
ID
Nemec Svete, Alenka
(
Avtor
),
ID
Tozon, Nataša
(
Avtor
),
ID
Pavlin, Darja
(
Avtor
)
PDF - Predstavitvena datoteka,
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(873,00 KB)
MD5: F64BC23AED737303BD4442F327D81F56
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-2615/14/12/1813
Galerija slik
Izvleček
Chronic kidney disease (CKD) is characterized by chronic inflammation, which mediates the progressive replacement of functional nephrons by fibrotic tissue. Hemogram-derived inflammatory markers are known to serve as markers of pathological conditions; however, their diagnostic value in feline CKD is still unknown. The aim of this retrospective study was to investigate selected hemogram-derived inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) and the systemic immune-inflammatory index (SII)) in cats at different clinical stages of CKD. Eighty-eight client-owned cats with CKD and thirty-two healthy control cats were included. Cats with CKD were divided into two groups: early CKD (IRIS stage 1 and 2; 62 cats) and progressed CKD (IRIS stage 3 and 4; 26 cats). The values of inflammatory markers were compared between the two CKD groups and the control group. All investigated hemogram-derived inflammatory markers were significantly (p < 0.05) greater in cats with advanced CKD than in those in the other two groups. Additionally, we demonstrated a statistically significant weak to moderate correlation between serum urea, creatinine, selected hematologic and urinary parameters, and the investigated inflammatory markers in cats with CKD. Chronic inflammation can be easily and inexpensively assessed with hemogram-derived markers.
Jezik:
Angleški jezik
Ključne besede:
chronic kidney disease
,
cats
,
hemogram-derived inflammatory markers
,
neutrophil-to-lymphocyte ratio
,
monocyte-to-lymphocyte ratio
,
platelet-to-lymphocyte ratio
,
systemic immune-inflammatory index
,
renal insufficiency
,
chronic
,
inflammation
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
13 str.
Številčenje:
Vol. 14, iss. 12, art. 1813
PID:
20.500.12556/RUL-158639
UDK:
636.8:616
ISSN pri članku:
2076-2615
DOI:
10.3390/ani14121813
COBISS.SI-ID:
199222275
Datum objave v RUL:
18.06.2024
Število ogledov:
160
Število prenosov:
42
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Objavi na:
Gradivo je del revije
Naslov:
Animals
Skrajšan naslov:
Animals
Založnik:
MDPI AG
ISSN:
2076-2615
COBISS.SI-ID:
519120409
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
18.06.2024
Projekti
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P4-0053
Naslov:
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
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