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Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals : evaluation of their impact on skin barrier function
ID
Vitek, Mercedes
(
Avtor
),
ID
Gosenca Matjaž, Mirjam
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,38 MB)
MD5: BDED1679788AC05F34BC6E871E725FC4
URL - Izvorni URL, za dostop obiščite
https://acta.pharmaceutica.farmaceut.org/wp-content/uploads/2024/05/30124.pdf
Galerija slik
Izvleček
The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients' quality of life, thus, there is a growing interest in development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single group trial with healthy adult subjects and twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar microstructure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short-and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.
Jezik:
Angleški jezik
Ključne besede:
lamellar liquid crystals
,
atopic dermatitis
,
transepidermal water loss
,
stratum corneum hydration
,
erythema index
,
melanin index
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
Str. 301-313
Številčenje:
Vol. 74, no. 2
PID:
20.500.12556/RUL-158261
UDK:
616.5-002
ISSN pri članku:
1846-9558
DOI:
10.2478/acph-2024-0014
COBISS.SI-ID:
180928771
Datum objave v RUL:
31.05.2024
Število ogledov:
173
Število prenosov:
50
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Objavi na:
Gradivo je del revije
Naslov:
Acta pharmaceutica
Skrajšan naslov:
Acta pharm.
Založnik:
Croatian Pharmaceutical Society
ISSN:
1846-9558
COBISS.SI-ID:
3817585
Licence
Licenca:
CC BY-ND 4.0, Creative Commons Priznanje avtorstva-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nd/4.0/deed.sl
Opis:
Licenca Creative Commons Brez predelav dovoljuje uporabnikom ponovno distribucijo dela, vendar ne v spremenjeni obliki. Zahtevana je navedba avtorstva.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
dermatitis
,
nevrodermitis
,
lamelarni tekoči kristali
,
atopijski dermatitis
,
transepidermalna izguba vode
,
hidracija stratum corneuma
,
eritemski indeks
,
melaninski indeks
Projekti
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P1-0189
Naslov:
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
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