Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals : evaluation of their impact on skin barrier function

Vitek, Mercedes (author), Gosenca Matjaž, Mirjam (author)

The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients' quality of life, thus, there is a growing interest in development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single group trial with healthy adult subjects and twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar microstructure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short-and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.

• Language: English
• Keywords: lamellar liquid crystals, atopic dermatitis, transepidermal water loss, stratum corneum hydration, erythema index, melanin index
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 301-313
• Numbering: Vol. 74, no. 2
• PID: 20.500.12556/RUL-158261
• UDC: 616.5-002
• ISSN on article: 1846-9558
• DOI: 10.2478/acph-2024-0014
• COBISS.SI-ID: 180928771
• Publication date in RUL: 31.05.2024

Record is a part of a journal

• Title: Acta pharmaceutica
• Shortened title: Acta pharm.
• Publisher: Croatian Pharmaceutical Society
• ISSN: 1846-9558
• COBISS.SI-ID: 3817585

Licences

• License: CC BY-ND 4.0, Creative Commons Attribution-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nd/4.0/
• Description: Under the NoDerivatives Creative Commons license one can take a work released under this license and re-distribute it, but it cannot be shared with others in adapted form, and credit must be provided to the author.

Secondary language

• Language: Slovenian
• Keywords: dermatitis, nevrodermitis, lamelarni tekoči kristali, atopijski dermatitis, transepidermalna izguba vode, hidracija stratum corneuma, eritemski indeks, melaninski indeks

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0189
• Name: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih