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Silver(I) complexes with voriconazole as promising anti-Candida agents
ID
Stanković, Mia
(
Avtor
),
ID
Skaro-Bogojevic, Sanja
(
Avtor
),
ID
Kljun, Jakob
(
Avtor
),
ID
Milanović, Žiko
(
Avtor
),
ID
Stevanović, Nevena Lj.
(
Avtor
),
ID
Lazić, Jelena
(
Avtor
),
ID
Vojnović, Sandra
(
Avtor
),
ID
Turel, Iztok
(
Avtor
),
ID
Djuran, Miloš I.
(
Avtor
),
ID
Glišić, Biljana Đ.
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(4,80 MB)
MD5: 342C0CF170E04668E36B7E94F8BFDA3F
URL - Izvorni URL, za dostop obiščite
https://www.sciencedirect.com/science/article/pii/S0162013424000953
Galerija slik
Izvleček
Recognizing that metal ions play an important role in modifying the pharmacological properties of known organic-based drugs, the present manuscript addresses the complexation of the antifungal agent voriconazole (vcz) with the biologically relevant silver(I) ion as a strategy for the development of new antimycotics. The synthesized silver(I) complexes with vcz were characterized by mass spectrometry, IR, UV–Vis and NMR spectroscopy and single-crystal X-ray diffraction analysis. The crystallographic results showed that complexes {[Ag(vcz)(H$_2$O)]CH$_3$SO$_3$}$_n$ (1), {[Ag(vcz)$_2$]BF$_4$}$_n$ (2) and {[Ag(vcz)$_2$]PF$_6$}$_n$ (3) have polymeric structures in the solid state, in which silver(I) ions have a distorted tetrahedral geometry. On the other hand, DFT calculations revealed that the investigated silver(I) complexes 1–3 in DMSO exist as linear [Ag(vcz-N2)(vcz-N19)]$^+$ (1a), [Ag(vcz-N2)(vcz-N4)]$^+$ (2a) and [Ag(vcz-N4)$_2]^+$ (3a) species, respectively. The evaluated complexes showed an enhanced anti-Candida activity compared to the parent drug with minimal inhibitory concentration (MIC) values in the range of 0.02–1.05 μM. In comparison with vcz, the corresponding silver(I) complexes showed better activity in prevention hyphae and biofilm formation of C. albicans, indicating that they could be considered as promising agents against Candida that significantly inhibit its virulence. Also, these complexes are much better inhibitors of ergosterol synthesis in the cell membrane of C. albicans at the concentration of 0.5 × MIC. This is also confirmed by a molecular docking, which revealed that complexes 1a – 3a showed better inhibitory activity than vcz against the sterol 14α-demethylase enzyme cytochrome P450 (CYP51B), which plays a crucial role in the formation of ergosterol.
Jezik:
Angleški jezik
Ključne besede:
silver(I) complexes
,
voriconazole
,
coordination polymers
,
DFT calculations
,
anti-Candida activity
,
CYP51B
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
13 str.
Številčenje:
Vol. 256, art. 112572
PID:
20.500.12556/RUL-156101
UDK:
546.571
ISSN pri članku:
0162-0134
DOI:
10.1016/j.jinorgbio.2024.112572
COBISS.SI-ID:
194720259
Datum objave v RUL:
08.05.2024
Število ogledov:
223
Število prenosov:
50
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Journal of inorganic biochemistry
Skrajšan naslov:
J. inorg. biochem.
Založnik:
Elsevier
ISSN:
0162-0134
COBISS.SI-ID:
25752320
Licence
Licenca:
CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:
Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
srebrovi(I) kompleksi
,
vorikonazol
,
koordinacijski polimeri
,
kalkulacije DFT
,
protikandidna aktivnost
,
CYP51B
Projekti
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-66/2024-03/200042
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-65/2024-03/200122
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-66/2024-03/200122
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-66/2024-03/200378
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P1-0175
Naslov:
Napredna anorganska kemija
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
I0-0022
Naslov:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Serbian Academy of Sciences and Arts
Številka projekta:
F128
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Republic of Slovenia, Ministry of Education, Science and Sport, CMEPIUS, Mobility Grant
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
COST
Številka projekta:
CA21145
Akronim:
EURESTOP
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
University of Kragujevac, Faculty of Science, Bilateral project
Številka projekta:
19
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
University of Ljubljana, Faculty of Chemistry and Chemical Technology, Bilateral project
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