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Selection signatures reveal candidate genes for the Cornish Rex breed-specific phenotype
ID Zorc, Minja (Avtor), ID Horvat, Tajda (Avtor), ID Tanšek, Anja (Avtor), ID Ferme, Tamara (Avtor), ID Dovč, Peter (Avtor)

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Izvleček
Many coat color, behavioral and morphological traits are specific and fixed across cat breeds, with several variants influencing these traits being common among different breeds. In the domestic cat, rexoid mutations have been documented in several breeds. In the Cornish Rex, four bp deletion in the LPAR6 gene has been found to cause a frame shift and a premature stop codon. In addition to the rexoid coat, Cornish Rex cats also have a characteristic head, ear shape and body type. Analysis of the selection signatures in the Cornish Rex genome revealed several regions that are under selective pressure. One of these is located in CFA B4, in the region where the ALX1 gene is located. The ALX1 gene in Burmese cats disrupts the cranial morphogenesis and causes brachycephaly in the heterozygous state. In our study, we confirmed the presence of a deletion in LPAR6 in 20 Cornish Rex and in four F1 hybrids between Cornish Rex and domestic cat. However, we did not confirm the presence of the deletion in ALX1 in Cornish Rex cats. Genome-wide selection signature analysis was performed using ROH islands and integrated haplotype score (iHS) statistics based on publicly available SNP array data of 11 Cornish Rex cats. The selection signatures were detected on chromosomes A1, A3, C2, B1, B4 and D1.

Jezik:Angleški jezik
Ključne besede:cat, Cornish Rex, rex phenotype, selection signature, SNP array
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:14 str.
Številčenje:Vol. 15, iss. 3, art. 368
PID:20.500.12556/RUL-155309 Povezava se odpre v novem oknu
UDK:636.8:575
ISSN pri članku:2073-4425
DOI:10.3390/genes15030368 Povezava se odpre v novem oknu
COBISS.SI-ID:189424131 Povezava se odpre v novem oknu
Datum objave v RUL:28.03.2024
Število ogledov:276
Število prenosov:24
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Genes
Skrajšan naslov:Genes
Založnik:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:2073-4425
COBISS.SI-ID:523100185 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mačke, genetika, pasme, cornish rex, genotip, selekcija, kandidatni geni

Projekti

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P4-0220
Naslov:Primerjalna genomika in genomska biodiverziteta

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