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Final adult height in children with central precocious puberty – a retrospective study
ID
Knific, Taja
(
Avtor
),
ID
Lazarevič, Melisa
(
Avtor
),
ID
Žibert, Janez
(
Avtor
),
ID
Obolnar, Nika
(
Avtor
),
ID
Aleksovska, Nataša
(
Avtor
),
ID
Šuput Omladič, Jasna
(
Avtor
),
ID
Battelino, Tadej
(
Avtor
),
ID
Avbelj Stefanija, Magdalena
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,66 MB)
MD5: E4F595A9A476945C0513A07D81439A21
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fendo.2022.1008474/full
Galerija slik
Izvleček
Background/Aims: Central precocious puberty (CPP) is due to premature activation of the hypothalamic-pituitary-gonadal axis. It predominantly affects girls. CPP leads to lower final height (FH), yet the treatment benefit in girls between 6 and 8 years is equivocal. Our main goal was to evaluate the effects of gonadotropin-releasing hormone analog (GnRHa) on FH and identify factors that predict FH. Methods: In a retrospective study, children with CPP (12 boys, 81 girls) that reached FH were included. Their clinical data at diagnosis and up to their final height was compared by descriptive statistics among idiopathic (iCPP) (n=68) and non-idiopathic CPP (nCPP) and between GnRHa treated (n=48) and untreated (n=15) girls with iCPP. The treatment effect of body weight (BW) adjusted GnRHa dosing was evaluated. Univariate linear regression and step-wise multivariable regression including 48 girls with iCPP treated with GnRHa were performed to identify predicting factors for FH. Results: Children with idiopathic CPP (iCPP) reached higher FH (p=0.002) than children with non-idiopathic CPP. After the diagnosis, the treated group gained 7.0 cm more than the untreated group. Yet, attributable to individualized decision-making, the FH in both groups was comparable (161.5 cm in treated, 161.0 cm in untreated girls with iCPP), although the onset of menarche was 2.5 years earlier among untreated girls. BW-adjusted dosing suppressed peak luteinizing hormone (LH) below 4.5 IU/L in 95% of children; however, bone age further advanced during therapy in 38% of patients. Predicting factors revealed by multivariable regression were bone age at diagnosis, BMI SDS at diagnosis, LH basal, age at start and cessation of treatment, predicted adult height and target height. (R2 = 0.72). Conclusion: Children with nCPP had worse FH outcome compared to iCPP despite similar CPP onset and therapeutic characteristics. Treatment by GnRHa using BW-adjusted dosing was effective in delaying menarche onset and reaching target height in girls with iCPP. Multiple factors affecting FH outcome indicated individualized decision-making regarding therapeutic intervention remains challenging. In the treated patients, among the factors that can be influenced, height at treatment cessation most significantly influenced the outcome.
Jezik:
Angleški jezik
Ključne besede:
central precocious puberty
,
final adult height
,
gonadotropin-releasing hormone analog
,
triptorelin
,
growth
,
height prediction
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
ZF - Zdravstvena fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
13 str.
Številčenje:
Vol. 13, art. 1008474
PID:
20.500.12556/RUL-155254
UDK:
616-053.2
ISSN pri članku:
1664-2392
DOI:
10.3389/fendo.2022.1008474
COBISS.SI-ID:
133849859
Datum objave v RUL:
22.03.2024
Število ogledov:
455
Število prenosov:
22
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in endocrinology
Založnik:
Frontiers Research Foundation
ISSN:
1664-2392
COBISS.SI-ID:
3340154
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
osrednja prezgodnja puberteta
,
končna odrasla višina
,
gonadotropin-sproščujoči hormon analog
,
triptorelin
,
rast
,
napoved višine
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0343
Naslov:
Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih
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