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Preliminary investigation of organ-protective effects of fullerenol in vivo in acute toxicity during doxorubicin therapy in healthy pigs
ID
Injac, Rade
(
Avtor
),
ID
Djordjević, Aleksandar N.
(
Avtor
),
ID
Štrukelj, Borut
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(704,16 KB)
MD5: 3C1577C94A4AB10FF46582C9607AA65B
URL - Izvorni URL, za dostop obiščite
https://academic.oup.com/rpsppr/article/3/1/rqad038/7416848
Galerija slik
Izvleček
Objectives The potential protective effect of fullerenol [C$_{60}$(OH)$_{24}$, Frl], a strong antioxidant, was investigated at a single dose of 25 mg/kg, administered orally (per os; p.o.) and intraperitoneally (i.p.), in the liver, lung, kidney, heart and spleen of healthy pigs, prior to doxorubicin (Dox)-induced toxicity at a single i.p. dose of 10 mg/kg. Methods We used the F1 generation of an in-vivo pig model (whose parents were Swedish Landrace and Large Yorkshire) to explore whether Frl, administered 6 h for p.o. and 30 min for i.p. prior to Dox treatment, could protect organs against damage caused by oxidative stress. Key findings According to the macroscopic, haematological, biochemical and physiological results, Frl exerted a potential protective effect on all investigated organs (heart, liver, lung, spleen and kidney) in pigs after i.p. administration. However, the results from Frl p.o. administration were inconclusive, therefore warranting further investigation. Conclusions Frl at a low dose of 25 mg/kg demonstrated satisfactory organ protection against Dox-induced toxicity in healthy pigs after i.p. injection. However, additional follow-up studies in pig models of cancer and with longer Dox and Frl treatment periods would be required to further delineate the optimal and clinically relevant conditions for Frl administration.
Jezik:
Angleški jezik
Ključne besede:
fullerenol
,
doxorubicin
,
toxicity
,
antioxidants
,
pigs
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
15 str.
Številčenje:
Vol. 3, iss. 1, art. rqad038
PID:
20.500.12556/RUL-154824
UDK:
615
ISSN pri članku:
2754-5849
DOI:
10.1093/rpsppr/rqad038
COBISS.SI-ID:
186771459
Datum objave v RUL:
04.03.2024
Število ogledov:
259
Število prenosov:
26
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Objavi na:
Gradivo je del revije
Naslov:
RPS pharmacy and pharmacology reports
Skrajšan naslov:
RPS pharm. pharmacol. rep.
Založnik:
Oxford University Press, Royal Pharmaceutical Society
ISSN:
2754-5849
COBISS.SI-ID:
186769923
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
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