The trajectory of sarcopenia following diagnosis of prostate cancer : a systematic review and meta-analysis

Kovač-Blaž, Milena (avtor), Pavlin, Tina (avtor), Čavka, Luka (avtor), Ribnikar, Domen (avtor), Spazzapan, Simon (avtor), Templeton, Arnoud J. (avtor), Šeruga, Boštjan (avtor)

Introduction: Sarcopenia is a common skeletal muscle disorder in older people. Here we explore the prevalence of sarcopenia and its impact on men with prostate cancer. Materials and Methods: We searched PubMed, Embase, and Web of Science databases for relevant studies with an explicit definition of sarcopenia in men with prostate cancer which were published between years 2000 and 2022. Prevalence of sarcopenia and its association with time to biochemical recurrence (BCR), progression-free survival (PFS), non-cancer mortality, overall survival (OS), and treatment-related complications in men with prostate cancer were explored. The summary prevalence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated. Results: A total of 24 studies comprising 3,616 patients with early and advanced prostate cancer were included. The prevalence of sarcopenia and sarcopenic obesity was 43.8% (95% CI 19.2%–68.5%) and 24.0% (95% CI 5.0%–43.1%), respectively. Sarcopenia was not associated with a shorter time to BCR (HR 0.89, 95% CI 0.64–1.23, p = 0.48), a shorter PFS (HR 1.20, 95% CI 0.73–1.97, p = 0.48), or a shorter OS (HR 1.29, 95% CI 0.90–1.85, p = 0.16). In contrast, sarcopenia was significantly associated with a higher non-cancer mortality (HR 1.85, 95% CI 1.23–2.80, p = 0.003). In four out of five studies eligible for assessment, sarcopenia was not associated with an increased risk of treatment-related complications. Discussion: Sarcopenia increases the risk of death from other causes in men with prostate cancer. Patients with prostate cancer should be assessed and managed for sarcopenia in everyday clinical practice.

• Jezik: Angleški jezik
• Ključne besede: sarcopenia, sarcopenic obesity, prostate cancer, meta-analysis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 10 str.
• Številčenje: Vol. 14, iss. 7, art. 101594
• PID: 20.500.12556/RUL-153026
• UDK: 616.6
• ISSN pri članku: 1879-4068
• DOI: 10.1016/j.jgo.2023.101594
• COBISS.SI-ID: 160455683
• Datum objave v RUL: 14.12.2023

Gradivo je del revije

• Naslov: Journal of geriatric oncology
• Založnik: Elsevier
• ISSN: 1879-4068
• COBISS.SI-ID: 519697433

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: sarkopenija, sarkopenična debelost, rak prostate

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0321
• Naslov: Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka