Histologic changes of porcine portal vein anastomosis after electrochemotherapy with bleomycin

Stupan, Urban (author), Čemažar, Maja (author), Trotovšek, Blaž (author), Petrič, Miha (author), Tomažič, Aleš (author), Gašljević, Gorana (author), Ranković, Branislava (author), Seliškar, Alenka (author), Plavec, Tanja (author), Sredenšek, Jerneja (author), Plut, Jan (author), Štukelj, Marina (author), Lampreht Tratar, Urša (author), Jesenko, Tanja (author), Nemec Svete, Alenka (author), Serša, Gregor (author), Djokić, Mihajlo (author)

Electrochemotherapy (ECT) is used for treatment of unresectable abdominal malignancies. This study aims to show that ECT of porcine portal vein anastomosis is safe and feasible in order to extend the indications for margin attenuation after resection of locally advanced pancreatic carcinoma. No marked differences were found between the control group and ECT treated groups. Electroporation thus caused irreversible damage to the vascular smooth muscle cells in tunica media that could be due to the narrow irreversible electroporation zone that may occur near the electrodes, or due to vasa vasorum thrombosis in the tunica externa. Based on the absence of vascular complications, and similar histological changes in lienal vein anastomosis, we can conclude that ECT of portal vein anastomosis is safe and feasible.

• Language: English
• Keywords: electrochemotherapy, portal vein anastomosis, pancreatic cancer
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine; VF - Veterinary Faculty; ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 10 str.
• Numbering: Vol. 154, art. 108509
• PID: 20.500.12556/RUL-152847
• UDC: 616.3
• ISSN on article: 1878-562X
• DOI: 10.1016/j.bioelechem.2023.108509
• COBISS.SI-ID: 159036675
• Publication date in RUL: 08.12.2023

Record is a part of a journal

• Title: Bioelectrochemistry
• Publisher: Elsevier
• ISSN: 1878-562X
• COBISS.SI-ID: 23407109

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: elektrokemoterapija, anastomoza portalne vene, rak trebušne slinavke