Histologic changes of porcine portal vein anastomosis after electrochemotherapy with bleomycin

Stupan, Urban (avtor), Čemažar, Maja (avtor), Trotovšek, Blaž (avtor), Petrič, Miha (avtor), Tomažič, Aleš (avtor), Gašljević, Gorana (avtor), Ranković, Branislava (avtor), Seliškar, Alenka (avtor), Plavec, Tanja (avtor), Sredenšek, Jerneja (avtor), Plut, Jan (avtor), Štukelj, Marina (avtor), Lampreht Tratar, Urša (avtor), Jesenko, Tanja (avtor), Nemec Svete, Alenka (avtor), Serša, Gregor (avtor), Djokić, Mihajlo (avtor)

Electrochemotherapy (ECT) is used for treatment of unresectable abdominal malignancies. This study aims to show that ECT of porcine portal vein anastomosis is safe and feasible in order to extend the indications for margin attenuation after resection of locally advanced pancreatic carcinoma. No marked differences were found between the control group and ECT treated groups. Electroporation thus caused irreversible damage to the vascular smooth muscle cells in tunica media that could be due to the narrow irreversible electroporation zone that may occur near the electrodes, or due to vasa vasorum thrombosis in the tunica externa. Based on the absence of vascular complications, and similar histological changes in lienal vein anastomosis, we can conclude that ECT of portal vein anastomosis is safe and feasible.

• Jezik: Angleški jezik
• Ključne besede: electrochemotherapy, portal vein anastomosis, pancreatic cancer
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; VF - Veterinarska fakulteta ; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 10 str.
• Številčenje: Vol. 154, art. 108509
• PID: 20.500.12556/RUL-152847
• UDK: 616.3
• ISSN pri članku: 1878-562X
• DOI: 10.1016/j.bioelechem.2023.108509
• COBISS.SI-ID: 159036675
• Datum objave v RUL: 08.12.2023

Gradivo je del revije

• Naslov: Bioelectrochemistry
• Založnik: Elsevier
• ISSN: 1878-562X
• COBISS.SI-ID: 23407109

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: elektrokemoterapija, anastomoza portalne vene, rak trebušne slinavke