izpis_h1_title_alt

HFpEF and atrial fibrillation : the enigmatic interplay of dysmetabolism, biomarkers, and vascular endothelial dysfunction
ID Bosanac, Jure (Avtor), ID Straus, Lara (Avtor), ID Novaković, Marko (Avtor), ID Košuta, Daniel (Avtor), ID Božič, Mojca (Avtor), ID Tasič, Jerneja (Avtor), ID Jug, Borut (Avtor)

.pdfPDF - Predstavitvena datoteka, prenos (412,00 KB)
MD5: 8445A6DFDDED809BAFFB76F4AB0F483D
URLURL - Izvorni URL, za dostop obiščite https://www.hindawi.com/journals/dm/2022/9539676/ Povezava se odpre v novem oknu

Izvleček
Background: Heart failure with preserved ejection fraction (HFpEF) has a complex pathophysiology that encompasses systemic proinflammatory state and dysregulated levels of cardiometabolic and oxidative stress biomarkers. The prevalence of both HFpEF and atrial fibrillation (AF) is continuously rising, especially in the elderly. The aim of our study was to explore if there were any differences in biomarker levels and vascular function in the elderly patients with HFpEF with and without AF and to assess interconnections between clinically relevant biomarkers and cardiac and vascular function. Methods: This was a cross-sectional study of patients ≥ 65 years with HFpEF who were divided into 2 groups based on the presence or absence of AF. We have sonographically assessed echocardiographic parameters of left ventricular systolic and diastolic function and the peripheral vascular function parameters, namely, pulse wave velocity (PWV) and flow-mediated dilation (FMD). NT-proBNP, irisin, leptin, adiponectin, insulin-like growth factor 1 (IGF-1), and malondialdehyde (MDA) blood levels were determined. Results: Fifty-two patients (mean age 80 ± 7 years, 67% females) were included. Patients with HFpEF and AF had significantly lower levels of irisin (median 4.75 vs. 13.5 ng/mL, p = 0.007), leptin (median 9.5 vs. 15.0 ng/L, p = 0.023), and MDA (median 293 vs. 450 ng/mL, p = 0.017) and significantly higher values of NT-proBNP (median 2365 vs. 529 ng/L, p < 0.001) but not vascular function parameters, as compared to HFpEF patients without AF. MDA was significantly correlated with diastolic function (r = 0.395, p = 0.007) and FMD (r = 0.394, p = 0.011), while adiponectin was inversely associated with FMD (r = –0.325, p = 0.038) and left ventricular ejection fraction (r = –0.319, p = 0.029). Conclusions: Our results have demonstrated that patients with HFpEF and AF have significantly lower leptin, irisin, and MDA levels compared to patients with HFpEF but without AF. These results offer new insights into the complexity of vascular function and cardiometabolic and oxidative stress biomarkers in the context of HFpEF, AF, and aging.

Jezik:Angleški jezik
Ključne besede:atrial fibrillation, heart failure, ejection fraction
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:7 str.
Številčenje:Vol. 2022, art. 9539676
PID:20.500.12556/RUL-152338 Povezava se odpre v novem oknu
UDK:616.1
ISSN pri članku:1875-8630
DOI:10.1155/2022/9539676 Povezava se odpre v novem oknu
COBISS.SI-ID:141947139 Povezava se odpre v novem oknu
Datum objave v RUL:21.11.2023
Število ogledov:261
Število prenosov:35
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
:
Kopiraj citat
Objavi na:Bookmark and Share

Gradivo je del revije

Naslov:Disease markers
Založnik:Hindawi
ISSN:1875-8630
COBISS.SI-ID:516120089 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:atrijska fibrilacija, srčno popuščanje, iztisni delež

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:University Medical Centre Ljubljana, Intern tertiary grant

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0308
Naslov:Ateroskleroza in tromboza

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:V3-2104
Naslov:Sekundarna preventiva in kakovosti oskrbe po srčnem infarktu v slovenskih bolnišnicah ter analiza vpliva epidemije covid-19 na obravnavo aterosklerotične bolezni

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Nazaj