The early and simple diagnosis of Alzheimer's disease remains one of the major challenges associated with the disease, as current methods for direct detection of the disease are expensive and inaccessible. In this work, six new molecules are presented as potential fluorescent probes for the detection of already known biomarkers for Alzheimer's disease. The molecules all contain a 2-phenylnaphthalene backbone with an electron-donating N,N dimethylamine group at one end and various electron-withdrawing groups at the other. These compounds are characterized by a rod-like structure that allows binding to biomarkers and promotes fluorescence by the "push-pull" method. In addition to the complete synthesis and characterization of the molecules, we measured the absorption, emission and excitation spectra and determined their molar absorption coefficients and quantum yields. The probes showed good optical properties, such as the presence of a bathochromic effect and an increase in the Stokes shift, implying that they could potentially be used for the diagnosis of Alzheimer’s disease.
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