The adduct of tetronic acid and pyrazolone was synthesized following the Michael addition mechanism and later fully characterized. The reaction was catalyzed by an achiral organocatalyst. The obtained adduct was acetylated with acetic anhydride, but the reaction didn't occur. Consequently the methylation of the same Michael adduct was performed, with which the final product was obtained. The enantiomers were supposed to separate on a chiral HPLC column, but the separation failed. Another racemic adduct was synthesized with N-Boc protected tetramic acid and pyrazolone under Michael addition mechanism, where for the reaction an achiral catalyst was used as well.
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