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Oxidative stress markers cannot be used as endometriosis biomarkers in infertile patients
ID
Janša, Vid
(
Avtor
),
ID
Osredkar, Joško
(
Avtor
),
ID
Verdenik, Ivan
(
Avtor
),
ID
Lanišnik-Rižner, Tea
(
Avtor
),
ID
Ban, Helena
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,13 MB)
MD5: 678888CCF8E45FB5106E7ADBB7FA4AD0
URL - Izvorni URL, za dostop obiščite
https://www.tandfonline.com/doi/full/10.1080/09513590.2023.2242956
Galerija slik
Izvleček
Objectives: Endometriosis is a common benign gynaecological disease that significantly compromises the quality of life of patients. To date, invasive surgery is the method of choice to visually and histologically confirm endometriosis. Thus, there is a major interest to develop noninvasive diagnostic tools. Oxidative stress is one of the proposed mechanisms of pathogenesis and may be involved in pelvic pain, dysmenorrhea, dyspareunia, and infertility in endometriosis patients. Thus, markers of oxidative stress may serve as diagnostic biomarkers for endometriosis. Design: This prospective case–control study assessed erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPX), serum hexanoyl lysine (HEL) and peritoneal fluid HEL. Participants/Materials, Setting, and Methods: We enrolled 86 women with primary infertility; the case group included 57 women with endometriosis, and the control group included 29 women with unexplained primary infertility. All the patients underwent laparoscopy, and the diagnosis was confirmed histologically. RANDOX and RANSEL reagents were used to determine the levels of SOD and GPX, respectively, and ELISA was used to determine the levels of HEL. Results: We found no statistically significant differences in the erythrocyte levels of GPX (p value 0.623) or SOD (p value 0.122) or the serum or peritoneal fluid levels of HEL (p value 0.562 and 0.329 accordingly). Conclusions: SOD, GPX, and HEL levels most likely do not differ between patients with unexplained infertility and patients with endometriosis.
Jezik:
Angleški jezik
Ključne besede:
oxidative stress biomarkers
,
endometriosis
,
superoxide dismutase
,
glutathione peroxidase
,
hexanoyl lysine
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
6 str.
Številčenje:
Vol. 39, no. 1
PID:
20.500.12556/RUL-148655
UDK:
612.015:618.14
ISSN pri članku:
0951-3590
DOI:
10.1080/09513590.2023.2242956
COBISS.SI-ID:
162356739
Datum objave v RUL:
29.08.2023
Število ogledov:
471
Število prenosov:
38
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Objavi na:
Gradivo je del revije
Naslov:
Gynecological endocrinology
Skrajšan naslov:
Gynecol. endocrinol.
Založnik:
Taylor and Francis Group
ISSN:
0951-3590
COBISS.SI-ID:
9017561
Licence
Licenca:
CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:
Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
biomarkerji oksidativnega stresa
,
superoksid dismutaza
,
glutation peroksidaza
,
heksanoil lizin
,
oksidativni stres
,
porodništvo
,
endometrioza
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0390
Naslov:
Funkcijska genomika in biotehnologija za zdravje
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