20.500.12556/RUL-148655 Oxidative stress markers cannot be used as endometriosis biomarkers in infertile patients Objectives: Endometriosis is a common benign gynaecological disease that significantly compromises the quality of life of patients. To date, invasive surgery is the method of choice to visually and histologically confirm endometriosis. Thus, there is a major interest to develop noninvasive diagnostic tools. Oxidative stress is one of the proposed mechanisms of pathogenesis and may be involved in pelvic pain, dysmenorrhea, dyspareunia, and infertility in endometriosis patients. Thus, markers of oxidative stress may serve as diagnostic biomarkers for endometriosis. Design: This prospective case–control study assessed erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPX), serum hexanoyl lysine (HEL) and peritoneal fluid HEL. Participants/Materials, Setting, and Methods: We enrolled 86 women with primary infertility; the case group included 57 women with endometriosis, and the control group included 29 women with unexplained primary infertility. All the patients underwent laparoscopy, and the diagnosis was confirmed histologically. RANDOX and RANSEL reagents were used to determine the levels of SOD and GPX, respectively, and ELISA was used to determine the levels of HEL. Results: We found no statistically significant differences in the erythrocyte levels of GPX (p value 0.623) or SOD (p value 0.122) or the serum or peritoneal fluid levels of HEL (p value 0.562 and 0.329 accordingly). Conclusions: SOD, GPX, and HEL levels most likely do not differ between patients with unexplained infertility and patients with endometriosis. oxidative stress biomarkers endometriosis superoxide dismutase glutathione peroxidase hexanoyl lysine biomarkerji oksidativnega stresa superoksid dismutaza glutation peroksidaza heksanoil lizin oksidativni stres porodništvo endometrioza true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-29 08:05:53 2023-08-29 08:05:58 2023-08-30 03:40:24 0000-00-00 00:00:00 2023 0 0 6 str. no. 1 Vol. 39 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612.015:618.14 0951-3590 10.1080/09513590.2023.2242956 162356739 Oxidative_stress_markers_cannot_be_used_as_endometriosis_biomarkers_in_infertile_patients.pdf Oxidative_stress_markers_cannot_be_used_as_endometriosis_biomarkers_in_infertile_patients.pdf 1 678888CCF8E45FB5106E7ADBB7FA4AD0 a8c945f247c7bbc6f96cb3456ce2bf02dd951b7f9061b47b8a3cd1ad64abfb49 8597ed51-4632-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172944 https://www.tandfonline.com/doi/full/10.1080/09513590.2023.2242956 1 1eb6388a-4632-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172943 Medicinska fakulteta Fakulteta za farmacijo 0 0 0