What is relative survival and what is its role in haematology?

Pohar Perme, Maja (avtor), Wreede, Liesbeth C. de (avtor), Manevski, Damjan (avtor)

In many haematological diseases, the survival probability is the key outcome. However, when the population of patients is rather old and the follow-up long, a significant proportion of deaths cannot be attributed to the studied disease. This lessens the importance of common survival analysis measures like overall survival and shows the need for other outcome measures requiring more complex methodology. When disease-specific information is of interest but the cause of death is not available in the data, relative survival methodology becomes crucial. The idea of relative survival is to merge the observed data set with the mortality data in the general population and thus allow for an indirect estimation of the burden of the disease. In this work, an overview of different measures that can be of interest in the field of haematology is given. We introduce the crude mortality that reports the probability of dying due to the disease of interest; the net survival that focuses on excess hazard alone and presents the key measure in comparing the disease burden of patients from populations with different general population mortality; and the relative survival ratio which gives a simple comparison of the patients' and the general population survival. We explain the properties of each measure, and some brief notes are given on estimation. Furthermore, we describe how association with covariates can be studied. All the methods and their estimators are illustrated on a sub-cohort of older patients who received a first allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes or secondary acute myeloid leukemia, to show how different methods can provide different insights into the data.

• Jezik: Angleški jezik
• Ključne besede: survival analysis, haematological diseases, mortality tables, relative survival, net survival, competing risks
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 11 str.
• Številčenje: Vol. 36, iss. 2, art. 101474
• PID: 20.500.12556/RUL-148276
• UDK: 616.1
• ISSN pri članku: 1532-1924
• DOI: 10.1016/j.beha.2023.101474
• COBISS.SI-ID: 151566851
• Datum objave v RUL: 09.08.2023

Gradivo je del revije

• Naslov: Best practice & research clinical haematology
• Skrajšan naslov: Baillière's best pract. res. clin. haematol.
• Založnik: Elsevier
• ISSN: 1532-1924
• COBISS.SI-ID: 151558659

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: analiza preživetja, hematološke bolezni, tabele smrtnosti

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0154
• Naslov: Metodologija za analizo podatkov v medicini

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-1761
• Naslov: Število izgubljenih let kot mera bremena bolezni