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The shape anisotropy of magnetic nanoparticles : an approach to cell-type selective and enhanced internalization
ID Potrč, Tanja (Author), ID Kralj, Slavko (Author), ID Nemec, Sebastjan (Author), ID Kocbek, Petra (Author), ID Erdani-Kreft, Mateja (Author)

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Abstract
The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namely magnetic nanochains (length ∼800 nm). Then, nanoparticle shape anisotropy is investigated on urothelial cells in vitro. Although both shapes of nanomaterials reveal biocompatibility, we have found significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation.

Language:English
Keywords:nanotechnology, anisotropic magnetic nanochains, cells in vitro, spherical particles
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2023
Number of pages:Str. 8611-8618
Numbering:Vol. 15, iss. 19
PID:20.500.12556/RUL-146395 This link opens in a new window
UDC:620.3:537
ISSN on article:2040-3364
DOI:10.1039/D2NR06965B This link opens in a new window
COBISS.SI-ID:150543875 This link opens in a new window
Publication date in RUL:29.05.2023
Views:460
Downloads:53
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Record is a part of a journal

Title:Nanoscale
Shortened title:Nanoscale
Publisher:Royal Society of Chemistry
ISSN:2040-3364
COBISS.SI-ID:23642407 This link opens in a new window

Licences

License:CC BY 3.0, Creative Commons Attribution 3.0 Unported
Link:https://creativecommons.org/licenses/by/3.0/deed.en
Description:You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Secondary language

Language:Slovenian
Keywords:nanotehnologija, anizotropne magnetne nanoverige, celice in vitro, sferični delci

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
Funder:ARRS - Slovenian Research Agency
Project number:P1-0420
Name:Napredna imunološka zdravila in celični pristopi v farmaciji
Funder:ARRS - Slovenian Research Agency
Project number:P2-0089
Name:Sodobni magnetni in večnamenski materiali
Funder:ARRS - Slovenian Research Agency
Project number:P3-0108
Name:Diferenciacija urotelijskih celic
Funder:ARRS - Slovenian Research Agency
Project number:J2-3043
Name:Izkoriščanje magneto-mehanskega učinka pri zdravljenju nevrodegenerativnih bolezni
Funder:ARRS - Slovenian Research Agency
Project number:J2-3040
Name:S posnemanjem endogenih lipidnih delcev do magnetno odzivnih nanostruktur za izboljšano dostavo zdravil in nanodelcev
Funder:ARRS - Slovenian Research Agency
Project number:J2-3046
Name:Selektivna elektroporacija s porazdeljenimi nanoelektrodami
Funder:ARRS - Slovenian Research Agency
Project number:J3-3079
Name:Baktericidna nanorezila: preizkus bimodalnega mehanokemijskega odstranjevanja trdovratnih biofilmov
Funder:ARRS - Slovenian Research Agency
Project number:J1-7302
Name:Nanoteranostiki na osnovi magnetno odzivnih materialov
Funder:ARRS - Slovenian Research Agency
Project number:J7-4420
Name:Selektivno mehansko odstranjevanje bakterijskih biofilmov s konjugiranimi magnetnimi nanodelci
Funder:ARRS - Slovenian Research Agency
Project number:J7-2594
Name:Uporaba amnijske membrane za inovativno multimodalno zdravljenje bakterijskega cistitisa in raka sečnega mehurja: učinek njene protimikrobne, imunomodulatorne in protirakave aktivnosti
Funder:ARRS - Slovenian Research Agency
Project number:BI-FR/23-24-PROTEUS-005
Funder:ARRS - Slovenian Research Agency
Project number:I0-0022
Name:Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)

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