The shape anisotropy of magnetic nanoparticles : an approach to cell-type selective and enhanced internalization

Potrč, Tanja (author), Kralj, Slavko (author), Nemec, Sebastjan (author), Kocbek, Petra (author), Erdani-Kreft, Mateja (author)

The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namely magnetic nanochains (length ∼800 nm). Then, nanoparticle shape anisotropy is investigated on urothelial cells in vitro. Although both shapes of nanomaterials reveal biocompatibility, we have found significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation.

• Language: English
• Keywords: nanotechnology, anisotropic magnetic nanochains, cells in vitro, spherical particles
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 8611-8618
• Numbering: Vol. 15, iss. 19
• PID: 20.500.12556/RUL-146395
• UDC: 620.3:537
• ISSN on article: 2040-3364
• DOI: 10.1039/D2NR06965B
• COBISS.SI-ID: 150543875
• Publication date in RUL: 29.05.2023

POTRČ, Tanja, KRALJ, Slavko, NEMEC, Sebastjan, KOCBEK, Petra and ERDANI-KREFT, Mateja, 2023, The shape anisotropy of magnetic nanoparticles : an approach to cell-type selective and enhanced internalization. Nanoscale [online]. 2023. Vol. 15, no. 19, p. 8611–8618. [Accessed 11 April 2025]. DOI 10.1039/D2NR06965B. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=146395

Record is a part of a journal

• Title: Nanoscale
• Shortened title: Nanoscale
• Publisher: Royal Society of Chemistry
• ISSN: 2040-3364
• COBISS.SI-ID: 23642407

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Secondary language

• Language: Slovenian
• Keywords: nanotehnologija, anizotropne magnetne nanoverige, celice in vitro, sferični delci