20.500.12556/RUL-146395 The shape anisotropy of magnetic nanoparticles an approach to cell-type selective and enhanced internalization The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namely magnetic nanochains (length ∼800 nm). Then, nanoparticle shape anisotropy is investigated on urothelial cells in vitro. Although both shapes of nanomaterials reveal biocompatibility, we have found significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation. nanotechnology anisotropic magnetic nanochains cells in vitro spherical particles nanotehnologija anizotropne magnetne nanoverige celice in vitro sferični delci true false true Angleški jezik Slovenski jezik Članek v reviji 2023-05-29 11:31:44 2023-05-29 11:31:47 2023-06-15 11:19:21 0000-00-00 00:00:00 2023 0 0 Str. 8611-8618 iss. 19 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 620.3:537 2040-3364 10.1039/D2NR06965B 150543875 d2nr06965b.pdf d2nr06965b.pdf 1 AA1C6742EFC67417A342E63CACEE29EA 43d2ec5c0dfb2a1db1b90d8cbebd1d432cdb63da500440982cec6f940a4065f3 206dbe6b-ff88-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=169589 https://pubs.rsc.org/en/content/articlelanding/2023/nr/d2nr06965b 1 56a87aa1-fe03-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=169575 Fakulteta za farmacijo Medicinska fakulteta 0 0 0