The Golgi complex : an organelle that determines urothelial cell biology in health and disease

Erdani-Kreft, Mateja (avtor), Mironov, Alexander A. (avtor), Hudoklin, Samo (avtor)

The Golgi complex undergoes considerable structural remodeling during differentiation of urothelial cells in vivo and in vitro. It is known that in a healthy bladder the differentiation from the basal to the superficial cell layer leads to the formation of the tightest barrier in our body, i.e., the blood–urine barrier. In this process, urothelial cells start expressing tight junctional proteins, apical membrane lipids, surface glycans, and integral membrane proteins, the uroplakins (UPs). The latter are the most abundant membrane proteins in the apical plasma membrane of differentiated superficial urothelial cells (UCs) and, in addition to well-developed tight junctions, contribute to the permeability barrier by their structural organization and by hindering endocytosis from the apical plasma membrane. By studying the transport of UPs, we were able to demonstrate their differentiation-dependent effect on the Golgi architecture. Although fragmentation of the Golgi complex is known to be associated with mitosis and apoptosis, we found that the process of Golgi fragmentation is required for delivery of certain specific urothelial differentiation cargoes to the plasma membrane as well as for cell–cell communication. In this review, we will discuss the currently known contribution of the Golgi complex to the formation of the blood–urine barrier in normal UCs and how it may be involved in the loss of the blood–urine barrier in cancer. Some open questions related to the Golgi complex in the urothelium will be highlighted.

• Jezik: Angleški jezik
• Ključne besede: Golgi complex, blood–urine barrier, urothelium, diferentiation, bladder cancer, uroplakins
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: Str. 229-240
• Številčenje: Vol. 158, iss. 3
• PID: 20.500.12556/RUL-145273
• UDK: 616.6
• ISSN pri članku: 0948-6143
• DOI: 10.1007/s00418-022-02121-0
• COBISS.SI-ID: 115936003
• Datum objave v RUL: 14.04.2023

Gradivo je del revije

• Naslov: Histochemistry and cell biology
• Založnik: Springer Nature
• ISSN: 0948-6143
• COBISS.SI-ID: 1401876

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: Golgijev aparat, krvno-urinska pregrada, urotelij