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Clonal spread of pESI-positive multidrug-resistant ST32 Salmonella enterica serovar Infantis isolates among broilers and humans in Slovenia
ID
Papić, Bojan
(
Avtor
),
ID
Kušar, Darja
(
Avtor
),
ID
Mićunović, Jasna
(
Avtor
),
ID
Pirš, Mateja
(
Avtor
),
ID
Ocepek, Matjaž
(
Avtor
),
ID
Avberšek, Jana
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,95 MB)
MD5: 97F8F9C58256861C6BE256C793628A10
URL - Izvorni URL, za dostop obiščite
https://journals.asm.org/doi/10.1128/spectrum.02481-22
Galerija slik
Izvleček
Salmonella enterica subsp. enterica serovar Infantis is the most prevalent serovar found in broilers and broiler meat and is among the top five serovars responsible for human infections in Europe. In 2008, a multidrug-resistant S. Infantis isolate emerged in Israel with a mosaic megaplasmid named pESI, associated with increased virulence, biofilm formation, and multidrug resistance. Since then, S. Infantis clones with pESI-like plasmids have been reported worldwide, replacing pESI-free clones. Here, we typed 161 S. Infantis isolates of poultry (n = 133) and human clinical (n = 28) origin using whole-genome sequencing. The isolates were collected between 2007 and 2021. In addition, we performed PacBio/Illumina sequencing for two representative pESI-like plasmids and compared them with publicly available sequences. All isolates belonged to sequence type 32 (ST32), except for one isolate that represented a novel single-locus variant of ST32. Core genome MLST (cgMLST) analysis revealed 14 clusters of genetically closely related isolates, of which four suggested broiler-to-human transmission of S. Infantis. pESI-like plasmids were present in 148/161 (91.9%) isolates; all were highly similar to the publicly available pESI-like sequences but lacked extended-spectrum beta-lactamase (ESBL) genes. PacBio/Illumina hybrid assembly allowed the reconstruction of two novel complete pESI variants. The present study revealed that the multidrug-resistant, pESI-positive S. Infantis clone became the predominant S. Infantis clone in Slovenian broilers and humans during the last decade. Continued surveillance of resistant S. Infantis clones along the food chain is needed to guide public health efforts.
Jezik:
Angleški jezik
Ključne besede:
Salmonella Infantis
,
ST32
,
pESI
,
multidrug resistance
,
broilers
,
humans
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
9 str.
Številčenje:
Vol. 10, no. 6, [article no.] e02481-22
PID:
20.500.12556/RUL-145025
UDK:
636.09:579
ISSN pri članku:
2165-0497
DOI:
10.1128/spectrum.02481-22
COBISS.SI-ID:
130438147
Datum objave v RUL:
30.03.2023
Število ogledov:
634
Število prenosov:
80
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Microbiology spectrum
Skrajšan naslov:
Microbiol. spectr.
Založnik:
ASM Press
ISSN:
2165-0497
COBISS.SI-ID:
4526968
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
30.03.2023
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
V4-2004
Naslov:
Obvladovanje okužb z bakterijo S. Infantis v rejah piščancev brojlerjev
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0092
Naslov:
Zdravje živali, okolje in varna hrana
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Ministry of Agriculture, Forestry and Food of Slovenia
Številka projekta:
V4-2004
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