Genetic variability in molecular pathways implicated in Alzheimer's disease : a comprehensive review

Vogrinc, David (avtor), Goričar, Katja (avtor), Dolžan, Vita (avtor)

Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant part of the population. The majority of AD cases occur in the elderly with a typical age of onset of the disease above 65 years. AD presents a major burden for the healthcare system and since population is rapidly aging, the burden of the disease will increase in the future. However, no effective drug treatment for a full-blown disease has been developed to date. The genetic background of AD is extensively studied; numerous genome-wide association studies (GWAS) identified significant genes associated with increased risk of AD development. This review summarizes more than 100 risk loci. Many of them may serve as biomarkers of AD progression, even in the preclinical stage of the disease. Furthermore, we used GWAS data to identify key pathways of AD pathogenesis: cellular processes, metabolic processes, biological regulation, localization, transport, regulation of cellular processes, and neurological system processes. Gene clustering into molecular pathways can provide background for identification of novel molecular targets and may support the development of tailored and personalized treatment of AD.

• Jezik: Angleški jezik
• Ključne besede: Alzheimer's disease, genetic risk factors, pathogenesis, genetics, biomarker, molecular pathways, gene ontology
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 30 str.
• Številčenje: Vol. 13, art. 646901
• PID: 20.500.12556/RUL-144670
• UDK: 616.8
• ISSN pri članku: 1663-4365
• DOI: 10.3389/fnagi.2021.646901
• COBISS.SI-ID: 57793283
• Datum objave v RUL: 07.03.2023

Gradivo je del revije

• Naslov: Frontiers in aging neuroscience
• Skrajšan naslov: Front. aging neurosci.
• Založnik: Frontiers Media
• ISSN: 1663-4365
• COBISS.SI-ID: 20576008

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: Alzheimerjeva bolezen, genetski dejavniki tveganja, patogeneza

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0170
• Naslov: Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku

• Financer: EC - European Commission
• Program financ.: H2020
• Številka projekta: 951851
• Naslov: Chair of Neuroinformatics
• Akronim: CONI