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Fabrication of antibacterial TiO$_2$ nanostructured surfaces using the hydrothermal method
ID Rawat, Niharika (Avtor), ID Benčina, Metka (Avtor), ID Gongadze, Ekaterina (Avtor), ID Junkar, Ita (Avtor), ID Iglič, Aleš (Avtor)

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Izvleček
Implant-associated infections (IAI) are a common cause for implant failure, increased medical costs, and critical for patient healthcare. Infections are a result of bacterial colonization, which leads to biofilm formation on the implant surface. Nanostructured surfaces have been shown to have the potential to inhibit bacterial adhesion mainly due to antibacterial efficacy of their unique surface nanotopography. The change in topography affects the physicochemical properties of their surface such as surface chemistry, morphology, wettability, surface charge, and even electric field which influences the biological response. In this study, a conventional and cost-effective hydrothermal method was used to fabricate nanoscale protrusions of various dimensions on the surface of Ti, Ti$_6$Al$_4$V, and NiTi materials, commonly used in biomedical applications. The morphology, surface chemistry, and wettability were analyzed using scanning electron microscopy (SEM), X-ray photoemission spectroscopy (XPS), and water contact angle analysis. The antibacterial efficacy of the synthesized nanostructures was analyzed by the use of Escherichia coli bacterial strain. XPS analysis revealed that the concentration of oxygen and titanium increased on Ti and Ti$_6$Al$_4$V, which indicates that TiO$_2$ is formed on the surface. The concentration of oxygen and titanium however decreased on the NiTi surface after hydrothermal treatment, and also a small amount of Ni was detected. SEM analysis showed that by hydrothermal treatment alterations in the surface topography of the TiO$_2$ layer could be achieved. The oxide layer on the NiTi prepared by the hydrothermal method contains a low amount of Ni (2.8 atom %), which is especially important for implantable materials. The results revealed that nanostructured surfaces significantly reduced bacterial adhesion on the Ti, Ti$_6$Al$_4$V, and NiTi surface compared to the untreated surfaces used as a control. Furthermore, two sterilization techniques were also studied to evaluate the stability of the nanostructure and its influence on the antibacterial activity. Sterilization with UV light seems to more efficiently inhibit bacterial growth on the hydrothermally modified Ti$_6$Al$_4$V surface, which was further reduced for hydrothermally treated Ti and NiTi. The developed nanostructured surfaces of Ti and its alloys can pave a way for the fabrication of antibacterial surfaces that reduce the likelihood of IAI.

Jezik:Angleški jezik
Ključne besede:titanium, surface modification, microstructure, nanostructure, cell response, biocompatibility, bacteria, implants, oxides, surface morphology, X-ray photoelectron spectroscopy
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FE - Fakulteta za elektrotehniko
ZF - Zdravstvena fakulteta
MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:Str. 47070-47077
Številčenje:Vol. 7, iss. 50
PID:20.500.12556/RUL-144317 Povezava se odpre v novem oknu
UDK:620.1/.2
ISSN pri članku:2470-1343
DOI:10.1021/acsomega.2c06175 Povezava se odpre v novem oknu
COBISS.SI-ID:133189379 Povezava se odpre v novem oknu
Datum objave v RUL:14.02.2023
Število ogledov:593
Število prenosov:46
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:ACS omega
Skrajšan naslov:ACS omega
Založnik:American Chemical Society
ISSN:2470-1343
COBISS.SI-ID:525873945 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

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