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Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms
ID Emond, Jean-Philippe (Avtor), ID Caron, Patrick (Avtor), ID Pušić Novak, Maja (Avtor), ID Turcotte, Véronique (Avtor), ID Simonyan, David (Avtor), ID Vogler, Andrej (Avtor), ID Osredkar, Joško (Avtor), ID Lanišnik-Rižner, Tea (Avtor), ID Guillemette, Chantal (Avtor)

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Izvleček
Objectives: Endometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain. The objective of this study was to evaluate whether estradiol (E$_2$) and its biologically active metabolites are differentially associated with EM given their estrogenic and non-estrogenic actions including proliferative and inflammatory properties. Design: We performed a retrospective study of 209 EM cases and 115 women without EM. Methods: Pain-related outcomes were assessed using surveys with validated scales. Preoperative serum levels of estradiol (E$_2$) and estrone (E$_1$), their 2-, 4- and 16- hydroxylated (OH) and methylated (MeO) derivatives (n=16) were measured by mass spectrometry. We evaluated the associations between estrogen levels and EM anatomic sites, surgical stage, risk of EM, and symptoms reported by women. Spearman correlations established the relationships between circulating steroids. Results: Of the sixteen estrogens profiled, eleven were detected above quantification limits in most individuals. Steroids were positively correlated, except 2-hydroxy 3MeO-E$_1$ (2OH-3MeO-E$_1$). Higher 2OH-3MeO-E$_1$ was linked to an increased risk of EM (Odd ratio (OR)=1.91 (95%CI 1.09-3.34); P=0.025). Ovarian EM cases displayed enhanced 2-hydroxylation with higher 2MeO-E$_1$ and 2OH-E$_1$ levels (P< 0.009). Abdominal, pelvic and back pain symptoms were also linked to higher 2OH-3MeO-E$_1$ levels (OR=1.86; 95%CI 1.06-3.27; P=0.032). Conclusions: The 2-hydroxylation pathway emerges as an unfavorable feature of EM, and is associated with ovarian EM and pain related outcomes.

Jezik:Angleški jezik
Ključne besede:endometriosis, catechol estrogens, steroids, mass spectrometry, pain symptoms
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2023
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:13 str.
Številčenje:Vol. 13, art. 1034614
PID:20.500.12556/RUL-143965 Povezava se odpre v novem oknu
UDK:618.1
ISSN pri članku:1664-2392
DOI:10.3389/fendo.2022.1034614 Povezava se odpre v novem oknu
COBISS.SI-ID:136322563 Povezava se odpre v novem oknu
Datum objave v RUL:24.01.2023
Število ogledov:52
Število prenosov:38
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Frontiers in endocrinology
Založnik:Frontiers Media
ISSN:1664-2392
COBISS.SI-ID:3340154 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:endometrioza, katehol estrogeni, steroidi

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Canadian Institutes of Health Research
Številka projekta:FRN-167269

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Canada Research Chair

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-1755
Naslov:Biokemijski označevalci endometrioze: študije transkriptoma in proteoma

Financer:EC - European Commission
Program financ.:H2020
Številka projekta:101008193
Naslov:Translational Research on Endometriosis
Akronim:TRENDO

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Fonds de recherche du Québec – Santé, Studentship award

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