Introduction: Pancreatic cancer is a disease that is usually discovered at an advanced stage. The patients' quality of life is greatly reduced, as they are often accompanied by problems. Stereotactic radiotherapy is one of the treatment options that is performed in a very short period of time. As an independent method of treatment, it provides excellent local control of the disease, which is comparable to surgery, and as a part of preoperative treatment, it provides a greater chance of complete removal of the tumor and ultimately reduces the patient's problems and improves his quality of life. Purpose: The purpose of the master's thesis is to present pancreatic cancer and its treatment with an emphasis on stereotactic radiotherapy. Methods: We used a descriptive method and systematic review of literature in the preparation of the master's thesis. For the purpose of writing the introduction, theoretical starting points and discussion, we used 78 sources of scientific literature, for the systematic review, we retained 22 sources, of total of 16536 identified sources, using the screening method. Results: The results include a document selection process for a systematic review and analysis of 22 sources of scientific literature, which we analyzed according to the purpose, findings and possible comments, and more specifically the number of participants, the most common total dose, the number of fractions, local control within 1 year, grade and proportion of acute toxicity and median survival. Discussion and conclusion: In borderline resectable patients, stereotactic radiotherapy can help to shrink the tumor and the involved vessel and enable complete surgical removal of the disease. In locally advanced tumors, that are unresectable, however, it enables a high level of local control, which is comparable in success to surgical resection. Steterotactic radiotherapy is suitable for pancreatic cancer recurrence after transitional radical resection (with an R0 resection margin) and for reirradiation after pancreatic cancer recurrence previously treated with conventional radiotherapy, as it also offers relief of problems, caused by tumour. Judging from a systematic review of literature, stereotactic radiotherpy for pancreatic cancer can achieve excellent one-year local control (73%) with a satisfactorily low level of toxicity.