Pregled literature o antioksidativnih učinkih koencima Q10 pri srčno-žilnih bolnikih

Jeram, Katarina (avtor), Mravljak, Janez (mentor)

Koencim Q10 je nizkomolekularni antioksidant endogenega izvora. Njegove glavne funkcije temeljijo na sposobnosti sprejemanja in oddajanja elektronov: sodeluje pri prenosu elektronov med kompleksi v mitohondrijski dihalni verigi in v procesu oksidativne fosforilacije, zavira lipidno peroksidacijo in je sposoben regenerirati α-tokoferol. Zato ima koencim Q10 pomembno vlogo tudi v procesu ateroskleroze, ki je vzrok za večino srčno-žilnih bolezni. Namen naloge je bilo izvesti sistematičen pregled vse dostopne literature, ki je obravnavala antioksidativne učinke koencima Q10 pri srčno-žilnih bolnikih oz. osebah z visokim tveganjem za srčno-žilna obolenja. Preučevani parametri so bili: superoksid dismutaza, malondialdehid, interlevkin 6, visoko občutljiv C-reaktivni protein, holesterol v lipoproteinih nizke gostote, vrednost od pretoka odvisne dilatacije. Sestavili smo ustrezen iskalni profil in literaturo iskali v podatkovnih bazah PubMed, Web of Science in Google Učenjak, pri čemer smo sledili načelom PRISMA. Od skupno 1738 zadetkov smo v literaturni pregled vključili 21 raziskav, ki so ustrezale vključitvenim kriterijem. Ocenili smo kakovost izbranih raziskav in za vsako izpisali osnovne podatke ter nato med seboj primerjali raziskave, ki so obravnavale paciente s primerljivim srčno-žilnim stanjem. Raziskave so pokazale na nekonsistentne povezave med uživanjem koencima Q10 in povišanjem aktivnosti SOD ter znižanjem koncentracije MDA. Glede protivnetnega učinka koencima Q10 so bili rezultati nasprotujoči. Raziskave niso pokazale konsistentnega pozitivnega učinka uživanja koencima Q10 na zniževanje koncentracije LDL-hol, pokazale pa so konsistenten pozitiven učinek na vrednost FMD pri osebah z visokim tveganjem za srčno-žilna obolenja. Na osnovi našega sistematičnega pregleda literature lahko zaključimo, da so raziskave pokazale na nekonsistentne antioksidativne učinke uživanja koencima Q10 in bi za zanesljive ugotovitve potrebovali več kakovostnih raziskav.

• Jezik: Slovenski jezik
• Ključne besede: Koencim Q10, antioksidant, srčno-žilne bolezni, literaturni pregled
• Vrsta gradiva: Magistrsko delo/naloga
• Organizacija: FFA - Fakulteta za farmacijo
• Leto izida: 2022
• PID: 20.500.12556/RUL-143480
• Datum objave v RUL: 22.12.2022

Sekundarni jezik

• Jezik: Angleški jezik
• Naslov: Literature review of coenzyme Q10 antioxidative effects in cardiovascular patients

Izvleček

Coenzyme Q10 is classified as one of the low molar mass antioxidants. Being able to accept and donor electrons is the basis of coenzyme Q10 activities: transporting electrons between protein complexes of the respiratory chain and participating in oxidative phosphorylation, preventing lipid peroxidation and being able to regenerate α-tocopherol. For this reason, coenzyme Q10 plays a significant role in the process of atherosclerosis, the cause of considerable number of cardiovascular diseases, as well. The aim of this master´s thesis was to carry out a systematic literature review of coenzyme Q10 antioxidative effects in cardiovascular patients and people with high risk for cardiovascular disease. Our main selected parameters were: superoxide dismutase activity, concentrations of malondialdehyde, interleukin 6, high sensitivity C-reactive protein, cholesterol in low density lipoproteins and value of flow mediated dilatation. While following PRISMA guidelines, we were searching for appropriate literature with our search profile in the databases PubMed, Web of Science and Google Scholar. From the total number of 1738 search results we selected 21 studies that met our inclusion criteria. We extracted data from selected studies. Afterwards, we compared the studies that examined comparable cardiovascular conditions. The studies indicated non-consistent connection between coenzyme Q10 intake and SOD activity increase and MDA concentration decrease. The results regarding coenzyme Q10 inflammatory effects were conflictive. The studies did not demonstrate consistent positive coenzyme Q10 effects on the LDL-hol concentration. However, studies did indicate consistent positive effects on FMD value in patients with considerable risk for cardiovascular diseases. Based on our literature review we conclude that studies indicated non-consistent antioxidant coenzyme Q10 effects and due to the limited data we would need more quality studies to be able to confirm these findings.

• Ključne besede: Coenzyme Q10, antioxidant, cardiovascular disease, literature review