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Application of FTIR spectroscopy to detect changes in skeletal muscle composition due to obesity with insulin resistance and STZ-induced diabetes
ID
Zupančič, Barbara
(
Avtor
),
ID
Umek, Nejc
(
Avtor
),
ID
Ugwoke, Chiedozie Kenneth
(
Avtor
),
ID
Cvetko, Erika
(
Avtor
),
ID
Horvat, Simon
(
Avtor
),
ID
Grdadolnik, Jože
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(2,25 MB)
MD5: 5C456A015C9035E332F6ED2574CFA22F
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/23/20/12498
Galerija slik
Izvleček
Age, obesity, and diabetes mellitus are pathophysiologically interconnected factors that significantly contribute to the global burden of non-communicable diseases. These metabolic conditions are associated with impaired insulin function, which disrupts the metabolism of carbohydrates, lipids, and proteins and can lead to structural and functional changes in skeletal muscle. Therefore, the alterations in the macromolecular composition of skeletal muscle may provide an indication of the underlying mechanisms of insulin-related disorders. The aim of this study was to investigate the potential of Fourier transform infrared (FTIR) spectroscopy to reveal the changes in macromolecular composition in weight-bearing and non-weight-bearing muscles of old, obese, insulin-resistant, and young streptozotocin (STZ)-induced diabetic mice. The efficiency of FTIR spectroscopy was evaluated by comparison with the results of gold-standard histochemical techniques. The differences in biomolecular phenotypes and the alterations in muscle composition in relation to their functional properties observed from FTIR spectra suggest that FTIR spectroscopy can detect most of the changes observed in muscle tissue by histochemical analyses and more. Therefore, it could be used as an effective alternative because it allows for the complete characterization of macromolecular composition in a single, relatively simple experiment, avoiding some obvious drawbacks of histochemical methods.
Jezik:
Angleški jezik
Ključne besede:
Fourier transform infrared (FTIR) spectroscopy
,
histochemical analysis
,
insulin resistance
,
obesity
,
diabetes
,
skeletal muscle macromolecular composition
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
22 str.
Številčenje:
Vol. 23, no. 20
PID:
20.500.12556/RUL-142154
UDK:
616
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms232012498
COBISS.SI-ID:
126210563
Datum objave v RUL:
21.10.2022
Število ogledov:
815
Število prenosov:
104
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
medicina
,
diabetes
,
debelost
,
mišji modeli
,
skeletne mišice
,
makromolekularna sestava
,
spektroskopija
,
FTIR
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0010
Naslov:
Folding in dinamika biomolekularnih sistemov
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0043
Naslov:
Molekularni mehanizmi razvoja in delovanja skeletne mišice
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0220
Naslov:
Primerjalna genomika in genomska biodiverziteta
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