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Protective role of mitochondrial uncoupling proteins against age-related oxidative stress in type 2 diabetes mellitus
ID
Čater, Maša
(
Avtor
),
ID
Križančić Bombek, Lidija
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,14 MB)
MD5: C06138DEE0EDE7E27358D4CDD49D87AC
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-3921/11/8/1473
Galerija slik
Izvleček
The accumulation of oxidative damage to DNA and other biomolecules plays an important role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus (T2D), atherosclerosis, and neurodegenerative disorders. Mitochondrial DNA (mtDNA) is especially sensitive to oxidative stress. Mitochondrial dysfunction resulting from the accumulation of mtDNA damage impairs normal cellular function and leads to a bioenergetic crisis that accelerates aging and associated diseases. Age-related mitochondrial dysfunction decreases ATP production, which directly affects insulin secretion by pancreatic beta cells and triggers the gradual development of the chronic metabolic dysfunction that characterizes T2D. At the same time, decreased glucose oxidation in skeletal muscle due to mitochondrial damage leads to prolonged postprandial blood glucose rise, which further worsens glucose homeostasis. ROS are not only highly reactive by-products of mitochondrial respiration capable of oxidizing DNA, proteins, and lipids but can also function as signaling and effector molecules in cell membranes mediating signal transduction and inflammation. Mitochondrial uncoupling proteins (UCPs) located in the inner mitochondrial membrane of various tissues can be activated by ROS to protect cells from mitochondrial damage. Mitochondrial UCPs facilitate the reflux of protons from the mitochondrial intermembrane space into the matrix, thereby dissipating the proton gradient required for oxidative phosphorylation. There are five known isoforms (UCP1-UCP5) of mitochondrial UCPs. UCP1 can indirectly reduce ROS formation by increasing glutathione levels, thermogenesis, and energy expenditure. In contrast, UCP2 and UCP3 regulate fatty acid metabolism and insulin secretion by beta cells and modulate insulin sensitivity. Understanding the functions of UCPs may play a critical role in developing pharmacological strategies to combat T2D. This review summarizes the current knowledge on the protective role of various UCP homologs against age-related oxidative stress in T2D.
Jezik:
Angleški jezik
Ključne besede:
uncoupling proteins
,
reactive oxygen species
,
aging
,
age-related diseases
,
diabetes
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
21 str.
Številčenje:
no. 8, art. 1473
PID:
20.500.12556/RUL-142153
UDK:
616:575
ISSN pri članku:
2076-3921
DOI:
10.3390/antiox11081473
COBISS.SI-ID:
118383363
Datum objave v RUL:
21.10.2022
Število ogledov:
464
Število prenosov:
68
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Antioxidants
Skrajšan naslov:
Antioxidants
Založnik:
MDPI
ISSN:
2076-3921
COBISS.SI-ID:
522976025
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
medicina
,
diabetes
,
staranje
,
oksidativni stres
,
genetika
,
poškodbe DNA
,
mitohondrijski DNA
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J3-9289
Naslov:
Vloga cikličnega adenozin monofosfata v normalni fiziologiji celic beta in med razvojem sladkorne bolezni tipa 2
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
N3-0133
Naslov:
Celice beta med razvojem in remisijo z dieto povzročene sladkorne bolezni
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0396
Naslov:
Celične in tkivne mreže
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