izpis_h1_title_alt

Mercury speciation in prenatal exposure in Slovenian and Croatian population - PHIME study
ID Trdin, Ajda (Avtor), ID Snoj Tratnik, Janja (Avtor), ID Mazej, Darja (Avtor), ID Fajon, Vesna (Avtor), ID Krsnik, Mladen (Avtor), ID Osredkar, Joško (Avtor), ID Prpić, Igor (Avtor), ID Špirić, Zdravko (Avtor), ID Petrović, Oleg (Avtor), ID Marc, Janja (Avtor), ID Neubauer, David (Avtor), ID Kodrič, Jana (Avtor), ID Kobal, Alfred Bogomir (Avtor), ID Barbone, Fabio (Avtor), ID Falnoga, Ingrid (Avtor), ID Horvat, Milena (Avtor)

.pdfPDF - Predstavitvena datoteka, prenos (718,92 KB)
MD5: D77FB605B3FA89E616E4074F0E8AC8E6
URLURL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0013935119304244?via%3Dihub Povezava se odpre v novem oknu

Izvleček
In recent years, several studies have addressed the issue of prenatal exposure to methylmercury (MeHg); however, few have actually analysed MeHg blood concentrations. Our study population included mothers and their new-borns from Slovenia (central region; N = 584) and Croatia (coastal region; N = 234). We have measurements of total Hg (THg) and MeHg in maternal hair, maternal peripheral blood, and cord blood. Cord blood Hg concentrations were low to moderate (median THg = 1.84 ng/g and MeHg = 1.69 ng/g). The proportion of THg as MeHg (%MeHg) in maternal and cord blood varied between 4% and 100% (coefficient of variation, CV = 32%) and between 8% and 100% (CV = 20%), respectively. Our data shows that variability of %MeHg was higher at lower blood THg levels. Concentrations of MeHg in maternal blood and cord blood were highly correlated (Rs = 0.943), in the case of inorganic Hg correlation was significant but weaker (Rs = 0.198). MeHg levels in maternal blood and cord blood were positively associated with seafood intake, maternal age, and negatively associated with pre-pregnancy BMI. Additionally, MeHg in maternal blood was positively associated with plasma selenium levels, and cord blood MeHg was negatively associated with parity. The results of multiple linear regression models showed that speciation analysis provides more defined estimation of prenatal exposure in association modelling. Associations between Hg exposure and cognitive performance of children (assessed using Bayley Scales of Infant and Toddler development) adjusted for maternal or child Apolipoprotein E genotypes showed higher model R2 and lower p-values when adjusted for MeHg compared to THg. This study demonstrates that Hg speciation improves the association between exposure and possible negative health effects.

Jezik:Angleški jezik
Ključne besede:ekologija, varstvo naravnih virov, ogrožanje okolja in njegovo varstvo
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Različica publikacije:Objavljena publikacija
Datum objave:01.01.2019
Leto izida:2019
Št. strani:Str. 108627-1-108627-10
Številčenje:art. 108627, Vol. 177
PID:20.500.12556/RUL-141294 Povezava se odpre v novem oknu
UDK:502/504
ISSN pri članku:0013-9351
DOI:10.1016/j.envres.2019.108627 Povezava se odpre v novem oknu
COBISS.SI-ID:32549415 Povezava se odpre v novem oknu
Datum objave v RUL:28.09.2022
Število ogledov:727
Število prenosov:51
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
:
Kopiraj citat
Objavi na:Bookmark and Share

Gradivo je del revije

Naslov:Environmental research. multidisciplinary journal of environmental sciences, ecology, and public health
Skrajšan naslov:Environ. res.
Založnik:Academic Press
ISSN:0013-9351
COBISS.SI-ID:3951911 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J7-9400-2018
Naslov:Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0143-2015
Naslov:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Nazaj