Halogenated ingredients of household and personal care products as emerging endocrine disruptors

Weiss, Veronika (avtor), Gobec, Martina (avtor), Jakopin, Žiga (avtor)

The everyday use of household and personal care products (HPCPs) generates an enormous amount of chemicals, of which several groups warrant additional attention, including: (i) parabens, which are widely used as preservatives; (ii) bisphenols, which are used in the manufacture of plastics; (iii) UV filters, which are essential components of many cosmetic products; and (iv) alkylphenol ethoxylates, which are used extensively as non-ionic surfactants. These chemicals are released continuously into the environment, thus contaminating soil, water, plants and animals. Wastewater treatment and water disinfection procedures can convert these chemicals into halogenated transformation products, which end up in the environment and pose a potential threat to humans and wildlife. Indeed, while certain parent HPCP ingredients have been confirmed as endocrine disruptors, less is known about the endocrine activities of their halogenated derivatives. The aim of this review is first to examine the sources and occurrence of halogenated transformation products in the environment, and second to compare their endocrine-disrupting properties to those of their parent compounds (i.e., parabens, bisphenols, UV filters, alkylphenol ethoxylates). Albeit previous reports have focused individually on selected classes of such substances, none have considered the problem of their halogenated transformation products. This review therefore summarizes the available research on these halogenated compounds, highlights the potential exposure pathways, and underlines the existing knowledge gaps within their toxicological profiles.

• Jezik: Angleški jezik
• Ključne besede: halogenated transformation products, parabens, bisphenols, UV filters, alkylphenol ethoxylates, endocrine disruption
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 19 str.
• Številčenje: Vol. 303, pt. 1, art. 134824
• PID: 20.500.12556/RUL-139093
• UDK: 612.43:620.266.1
• ISSN pri članku: 0045-6535
• DOI: 10.1016/j.chemosphere.2022.134824
• COBISS.SI-ID: 117775107
• Datum objave v RUL: 30.08.2022

Gradivo je del revije

• Naslov: Chemosphere
• Skrajšan naslov: Chemosphere
• Založnik: Elsevier
• ISSN: 0045-6535
• COBISS.SI-ID: 25213696

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: halogenirani produkti transformacije, parabeni, bisfenoli, UV filtri, alkilfenol etoksilati, endokrine motnje, hormonski motilci

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0208
• Naslov: Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0420
• Naslov: Napredna imunološka zdravila in celični pristopi v farmaciji