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Induced pluripotent stem cell (iPSC) line MLi004-A derived from a patient with recessive dystrophic epidermolysis bullosa (RDEB)
ID
Ropret, Sandra
(
Author
),
ID
Jeriha, Jakob
(
Author
),
ID
Sorčan, Tjaša
(
Author
),
ID
Rogar, Marija
(
Author
),
ID
Zemljič Jokhadar, Špela
(
Author
),
ID
McGrath, John A.
(
Author
),
ID
Ilic, Dusko
(
Author
),
ID
Liović, Mirjana
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S187350612100310X
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Abstract
We have generated MLi004-A, a new induced pluripotent stem cell (iPSC) line derived from skin fibroblasts of a female patient with recessive dystrophic epidermolysis bullosa (RDEB). This iPSC line may be used as a model system for studies on skin integrity, the extracellular matrix and skin barrier function. The characterization of the MLi004-A cell line consisted of molecular karyotyping, next-generation sequencing of the COL7A1 alleles, plu-ripotency and differentiation potentials testing by immunofluorescence of associated markers in vitro. The MLi004-A line has been also tested for ability to differentiate into fibroblasts.
Language:
English
Keywords:
stem cell
,
epidermolysis
,
collagen VII
,
recessive dystrophic EB
,
iPSC line
,
pluripotency
,
fibroblast
,
keratinocyte
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
5 str.
Numbering:
Vol. 55, art. 102463
PID:
20.500.12556/RUL-138881
UDC:
61
ISSN on article:
1876-7753
DOI:
10.1016/j.scr.2021.102463
COBISS.SI-ID:
74980611
Publication date in RUL:
24.08.2022
Views:
678
Downloads:
94
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Record is a part of a journal
Title:
Stem cell research
Publisher:
Elsevier
ISSN:
1876-7753
COBISS.SI-ID:
524165401
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Secondary language
Language:
Slovenian
Keywords:
matične celice
,
epidermoliza
,
kolagen VII
Projects
Funder:
Other - Other funder or multiple funders
Funding programme:
EMBO, Short-Term Fellowship
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
643271
Name:
Collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice
Acronym:
ERACoSysMed
Funder:
Other - Other funder or multiple funders
Funding programme:
Republic of Slovenia, Ministry of Education, Science and Sport (MIZŠ)
Acronym:
4D-HEALING
Funder:
Other - Other funder or multiple funders
Funding programme:
Celsa Alliance
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