Effects of coenzyme Q$_{10}$ supplementation on oxidative stress markers, inflammatory markers, lymphocyte subpopulations, and clinical status in dogs with myxomatous mitral valve disease

Druzhaeva, Natalia (avtor), Nemec Svete, Alenka (avtor), Tavčar-Kalcher, Gabrijela (avtor), Babič, Janja (avtor), Ihan, Alojz (avtor), Pohar, Katka (avtor), Krapež, Uroš (avtor), Domanjko-Petrič, Aleksandra (avtor)

Scarce data exist on the effects of coenzyme Q$_{10}$ (CoQ$_{10}$) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ$_{10}$ supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q$_{10}$ (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ$_{10}$ supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ$_{10}$ as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.

• Jezik: Angleški jezik
• Ključne besede: coenzyme Q$_{10}$, ubiquinone, supplementation, myxomatous mitral valve disease, congestive heart failure, dog, oxidative stress, inflammation, lymphocytes, neutrophils, coenzymes, heart failure
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 22 str.
• Številčenje: Vol. 11, iss. 8, art. 1427
• PID: 20.500.12556/RUL-138596
• UDK: 636.7.09:577:616
• ISSN pri članku: 2076-3921
• DOI: 10.3390/antiox11081427
• COBISS.SI-ID: 116770819
• Datum objave v RUL: 02.08.2022

Gradivo je del revije

• Naslov: Antioxidants
• Skrajšan naslov: Antioxidants
• Založnik: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0053
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih