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Capturing genetic diversity and selection signatures of the endangered Kosovar Balusha sheep breed
ID
Adeniyi, Olusegun O.
(
Avtor
),
ID
Simon, Rebecca
(
Avtor
),
ID
Bytyqi, Hysen
(
Avtor
),
ID
Kugler, Waltraud
(
Avtor
),
ID
Mehmeti, Hajrip
(
Avtor
),
ID
Berisha, Kaltrina
(
Avtor
),
ID
Simčič, Mojca
(
Avtor
),
ID
Magdy, Mohamed
(
Avtor
),
ID
Lühken, Gesine
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(4,05 MB)
MD5: 49B843C21A71F015ECB6E19276B4A4A2
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2073-4425/13/5/866
Galerija slik
Izvleček
There is a growing concern about the loss of animal genetic resources. The aim of this study was to analyze the genetic diversity and potential peculiarity of the endangered Kosovar sheep breed Balusha. For this purpose, a dataset consisting of medium-density SNP chip genotypes (39,879 SNPs) from 45 Balusha sheep was generated and compared with SNP chip genotypes from 29 individuals of a second Kosovar breed, Bardhoka. Publicly available SNP genotypes from 39 individuals of the relatively closely located sheep breeds Istrian Pramenka and Ruda were additionally included in the analyses. Analysis of heterozygosity, allelic richness and effective population size was used to assess the genetic diversity. Inbreeding was evaluated using two different methods (FIS, FROH). The standardized FST (di) and cross-population extended haplotype homozygosity (XPEHH) methods were used to detect signatures of selection. We observed the lowest heterozygosity (HO = 0.351) and effective population size (Ne5 = 25, Ne50 = 228) for the Balusha breed. The mean allelic richness levels (1.780–1.876) across all analyzed breeds were similar and also comparable with those in worldwide breeds. FROH estimates (0.023–0.077) were highest for the Balusha population, although evidence of decreased inbreeding was observed in FIS results for the Balusha breed. Two Gene Ontology (GO) TERMs were strongly enriched for Balusha, and involved genes belonging to the melanogenesis and T cell receptor signaling pathways, respectively. This could result from selection for the special coat color pattern of Balusha (black head) and resistance to certain infectious diseases. The analyzed diversity parameters highlight the urgency to preserve the local Kosovar Balusha sheep as it is clearly distinguished from other sheep of Southeastern Europe, has the lowest diversity level and may harbor valuable genetic variants, e.g., for resistance to infectious diseases.
Jezik:
Angleški jezik
Ključne besede:
ovis aries
,
conservation/preservation
,
population structure
,
ROH
,
GO TERMS
,
Pramenka
,
Balkan
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
18 str.
Številčenje:
Vol. 13, iss. 3, art. 866
PID:
20.500.12556/RUL-138132
UDK:
636.3
ISSN pri članku:
2073-4425
DOI:
10.3390/genes13050866
COBISS.SI-ID:
107822339
Datum objave v RUL:
11.07.2022
Število ogledov:
511
Število prenosov:
95
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Genes
Skrajšan naslov:
Genes
Založnik:
Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:
2073-4425
COBISS.SI-ID:
523100185
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
ovce
,
pasme
,
Balusha
,
genetski viri
,
ohranjanje
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
SAVE Foundation
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