As part of my thesis, I planned the synthesis of 1,3,4-thiadiazoles using model substrates. The synthesis was carried out by reaction between ketones and 4,4-dimethylthiosemicarbazide. Thiadiazoles, which are products of this reaction, are important in drug development because of their biological activities. I continued the optimization of synthetic processes of the compounds by changing the reaction conditions. Using the characterization methods (NMR, HRMS and CHN analysis), I confirmed the formation of the desired products. The compound prepared from 4- (trifluoromethyl)acetophenone crystallized and the structure was determined by X-ray structural analysis. The purity of thiadiazoles and the reaction yields could be improved by further optimization of synthetic procedures.
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