Protein release from nanocellulose and alginate hydrogels : the study of adsorption and desorption kinetics

Kopač, Tilen (avtor), Krajnc, Matjaž (avtor), Ručigaj, Aleš (avtor)

This work presents a study of the lysozyme release from crosslinked TEMPO nanocellulose (TOCNF) and alginate (ALG) hydrogels in a medium with different ionic strength and temperature. The main objective is to develop a mathematical model for a detailed study of the concurrent action of diffusion mechanism and adsorption/desorption kinetics. Model fit parameters provide important information about the initial (maximum) adsorption rate and its deceleration with increasing ionic strength of the release medium. Similarly, the initial (minimum) desorption rate and its acceleration with increasing salt concentration can be determined. The model leads us to the conclusion that the initial adsorption rate is higher in the case of TOCNF, but due to fewer electrostatic interactions and morphology as well as topography of the surface, it decreases to a negligible value much faster than in the case of ALG, where the diffusion process becomes dominant.

• Jezik: Angleški jezik
• Ključne besede: lysozyme, adsorption, TEMPO nanocellulose, alginate, controlled protein release, mathematical modeling
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 10 str.
• Številčenje: Vol. 217, art. 112677
• PID: 20.500.12556/RUL-137871
• UDK: 678:544.4
• ISSN pri članku: 0927-7765
• DOI: 10.1016/j.colsurfb.2022.112677
• COBISS.SI-ID: 113668355
• Datum objave v RUL: 05.07.2022

Gradivo je del revije

• Naslov: Colloids and surfaces. B, Biointerfaces
• Skrajšan naslov: Colloids surf., B, Biointerfaces
• Založnik: Elsevier
• ISSN: 0927-7765
• COBISS.SI-ID: 15329029

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: lizocim, adsorpcija, TEMPO nanoceluloza, alginat, kontrolirano sproščanje proteina, matematično modeliranje, polimeri

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P2-0191
• Naslov: Kemijsko inženirstvo