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The influence of different mechanical stress on the release properties of HPMC matrix tablets in sucrose-NaCl media
ID
Vrbanac, Helena
(
Avtor
),
ID
Krese, Ana
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,99 MB)
MD5: 02AE99B64BB07F57F52B2C029F4E305A
URL - Izvorni URL, za dostop obiščite
https://www.sciencedirect.com/science/article/pii/S1773224719308226
Galerija slik
Izvleček
Four types of HPMC matrix tablets were studied to investigate the influence of mechanical stress on matrix behaviour using biorelevant in vitro dissolution model, the glass bead device (GBD) and paddle apparatus (USP2), in media with various concentrations of sucrose and NaCl. High or low viscosity grade HPMC was incorporated in the matrix with soluble (lactose) and insoluble (microcrystalline cellulose) diluent. The composition of the tablets and dissolution media were selected based on available literature data, with the intention of providing a sensitive system to reflect differences in hydrodynamics and mechanical stress generated by dissolution apparatuses. Between the GBD and USP2 no substantial differences were demonstrated in low concentration media. The differences were induced in high concentration media; compared to USP2 a higher drug release was observed in GBD for each matrix type. Due to solutes in the media an incoherent gel layer is formed and therefore the matrices are more prone towards the hydrodynamic and mechanical stress of dissolution method, suggesting that motion on the surface of glass beads is an important parameter that affects the removal of the gel layer. In critical media where formation of the functional gel barrier might be compromised, the use of GBD could provide additional insight into the drug release behaviour of the matrix tablet.
Jezik:
Angleški jezik
Ključne besede:
HPMC matrix tablets
,
biorelevant dissolution testing
,
sucrose
,
NaCl
,
erosion
,
glass bead device
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2019
Št. strani:
9 str.
Številčenje:
Vol. 54, art. 101246
PID:
20.500.12556/RUL-137726
UDK:
615
ISSN pri članku:
1773-2247
DOI:
10.1016/j.jddst.2019.101246
COBISS.SI-ID:
1554270
Datum objave v RUL:
29.06.2022
Število ogledov:
670
Število prenosov:
102
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Journal of drug delivery science and technology
Skrajšan naslov:
J. drug deliv. sci. technol.
Založnik:
Elsevier
ISSN:
1773-2247
COBISS.SI-ID:
2045297
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
nanomateriali
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