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Ibogaine-mediated ROS/antioxidant elevation in isolated rat uterus is β-adrenergic receptors and K$_{ATP}$ channels mediated
ID
Tatalović, Nikola
(
Avtor
),
ID
Vidonja-Uzelac, Teodora
(
Avtor
),
ID
Oreščanin-Dušić, Zorana
(
Avtor
),
ID
Nikolić-Kokić, Aleksandra
(
Avtor
),
ID
Bresjanac, Mara
(
Avtor
),
ID
Blagojević, Duško
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,92 MB)
MD5: 9526FE62307F098D6B9800DFDA3AC304
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-3921/10/11/1792
Galerija slik
Izvleček
Ibogaine effects are mediated by cellular receptors, ATP depletion followed by ROS production and antioxidant enzyme activity elevation in a dose and time dependent manner. Since the role of K$_{ATP}$ channels and β-adrenoceptors in ROS cellular circuit was established here we explored their role in ibogaine pro-antioxidant effectiveness. Single dose of ibogaine (10 mg/L i.e., 28.8 µmol/L) was applied to isolated rat uterus (spontaneous and Ca$^{2+}$-stimulated) and contractility and antioxidant enzymes activity were monitored during 4 h. Ibogaine increased amplitude and frequency of spontaneous active uteri immediately after addition that was prevented by propranolol (β$_1$ and β$_2$ adrenoceptors selective antagonists) and glibenclamide (K$_{ATP}$ sensitive channels inhibitor; only frequency) pre-treatment. In Ca$^{2+}$-stimulated uteri, ibogaine decreased both amplitude and frequency after 4 h. Pre-treatment with propranolol abolished ibogaine induced amplitude lowering, while glibenclamide had no effect. In both types of active uterus, ibogaine induced a decrease in SOD1 and an increase in CAT activity after 2 h. In Ca$^{2+}$-stimulated uterus, there was also a decrease of SOD2 activity after 2 h. After 4 h, SOD1 activity returned to the baseline level, but GSH-Px activity increased. Pre-treatment with both propranolol and glibenclamide abolished observed changes of antioxidant enzymes activity suggesting that ibogaine pro-antioxidative effectiveness is β-adrenergic receptors and K$_{ATP}$ channels mediated.
Jezik:
Angleški jezik
Ključne besede:
ibogaine
,
K$_{ATP}$ channels
,
glibenclamide
,
β-adrenergic receptors
,
propranolol
,
antioxidative enzymes
,
superoxide dismutase
,
catalase
,
uterus
,
contractility
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
16 str.
Številčenje:
Vol. 10, iss. 11, art. 1792
PID:
20.500.12556/RUL-137417
ISSN pri članku:
2076-3921
DOI:
10.3390/antiox10111792
COBISS.SI-ID:
140497923
Datum objave v RUL:
16.06.2022
Število ogledov:
632
Število prenosov:
104
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Antioxidants
Skrajšan naslov:
Antioxidants
Založnik:
MDPI
ISSN:
2076-3921
COBISS.SI-ID:
522976025
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
ibogain
,
K$_{ATP}$ kanali
,
glibenklamid
,
β-adrenergični receptorji
,
propranolol
,
antioksidativni encimi
,
superoksid dismutaza
,
katalaza
,
maternica
,
kontraktilnost
Projekti
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-68/2020-14/200007
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0171
Naslov:
Plastičnost živčevja v fizioloških in patofizioloških razmerah
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