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Skeletal muscle microvascular dysfunction in obesity-related insulin resistance : pathophysiological mechanisms and therapeutic perspectives
ID
Ugwoke, Chiedozie Kenneth
(
Avtor
),
ID
Cvetko, Erika
(
Avtor
),
ID
Umek, Nejc
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(837,46 KB)
MD5: 530B6720492D077B6504B50E4F0B2E76
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/23/2/847
Galerija slik
Izvleček
Obesity is a worrisomely escalating public health problem globally and one of the leading causes of morbidity and mortality from noncommunicable disease. The epidemiological link between obesity and a broad spectrum of cardiometabolic disorders has been well documented; however, the underlying pathophysiological mechanisms are only partially understood, and effective treatment options remain scarce. Given its critical role in glucose metabolism, skeletal muscle has increasingly become a focus of attention in understanding the mechanisms of impaired insulin function in obesity and the associated metabolic sequalae. We examined the current evidence on the relationship between microvascular dysfunction and insulin resistance in obesity. A growing body of evidence suggest an intimate and reciprocal relationship between skeletal muscle microvascular and glucometabolic physiology. The obesity phenotype is characterized by structural and functional changes in the skeletal muscle microcirculation which contribute to insulin dysfunction and disturbed glucose homeostasis. Several interconnected etiologic molecular mechanisms have been suggested, including endothelial dysfunction by several factors, extracellular matrix remodelling, and induction of oxidative stress and the immunoinflammatory phenotype. We further correlated currently available pharmacological agents that have deductive therapeutic relevance to the explored pathophysiological mechanisms, highlighting a potential clinical perspective in obesity treatment.
Jezik:
Angleški jezik
Ključne besede:
microvascular dysfunction
,
insulin resistance
,
obesity treatment
,
obesity
,
skeletal muscle
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
22 str.
Številčenje:
Vol. 23, iss. 2, art. 847
PID:
20.500.12556/RUL-137128
UDK:
611
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms23020847
COBISS.SI-ID:
93446147
Datum objave v RUL:
01.06.2022
Število ogledov:
854
Število prenosov:
127
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
13.01.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
mikrovaskularna disfunkcija
,
odpornost proti insulinu
,
zdravljenje debelosti
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0043
Naslov:
Molekularni mehanizmi razvoja in delovanja skeletne mišice
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