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Histopathological and immunohistochemical evaluation of canine nerve sheath tumors and proposal for an update classification
ID
Tekavec, Kristina
(
Avtor
),
ID
Švara, Tanja
(
Avtor
),
ID
Knific, Tanja
(
Avtor
),
ID
Gombač, Mitja
(
Avtor
),
ID
Cantile, Carlo
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(6,97 MB)
MD5: A6976056474FA364F3FB691DB6E61DCC
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2306-7381/9/5/204
Galerija slik
Izvleček
Nerve sheath tumors are a group of tumors originating from Schwann cells, fibroblasts, and perineurial cells. In veterinary pathology, the terminology for nerve sheath tumors remains inconsistent, and many pathologists follow the human classification of such tumors in practice. Immunohistochemistry plays an important role in the diagnosis of nerve sheath tumors, but specific immunohistochemical and molecular biomarkers are lacking. In our study, we histopathologically reevaluated 79 canine nerve sheath tumors and assessed their reactivity for the immunohistochemical markers Sox10, claudin-1, GFAP, CNPase, and Ki-67. Based on the results, we classified the tumors according to the most recent human classification. Twelve cases were diagnosed as benign nerve sheath tumors, including six neurofibromas, three nerve sheath myxomas, two hybrid nerve sheath tumors (perineurioma/neurofibroma and perineurioma/schwannoma), and one schwannoma. Sixty-seven tumors were malignant nerve sheath tumors, including fifty-six conventional, four perineural, one epithelioid malignant nerve sheath tumor, and six malignant nerve sheath tumors with divergent differentiation. We believe that with the application of the proposed panel, an updated classification of canine nerve sheath tumors could largely follow the recent humanWHOclassification of tumors of the cranial and paraspinal nerves, but prospective studies would be needed to assess its prognostic value.
Jezik:
Angleški jezik
Ključne besede:
dog
,
nerve sheath tumor
,
histopathology
,
immunohistochemistry
,
Sox10
,
claudin-1
,
GFAP
,
CNPase
,
Ki-67
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
27 str.
Številčenje:
Vol. 9, no. 5, art. 204
PID:
20.500.12556/RUL-137092
UDK:
636.09:616-006
ISSN pri članku:
2306-7381
DOI:
10.3390/vetsci9050204
COBISS.SI-ID:
106797315
Datum objave v RUL:
01.06.2022
Število ogledov:
545
Število prenosov:
81
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Veterinary sciences
Skrajšan naslov:
Vet. sci.
Založnik:
MDPI
ISSN:
2306-7381
COBISS.SI-ID:
523429657
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.06.2022
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0092
Naslov:
Zdravje živali, okolje in varna hrana
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