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Ibogaine has sex-specific plasma bioavailability, histopathological and redox/antioxidant effects in rat liver and kidneys : a study on females
ID Tatalović, Nikola (Author), ID Vidonja-Uzelac, Teodora (Author), ID Mijović, Milica (Author), ID Koželj, Gordana (Author), ID Nikolić-Kokić, Aleksandra (Author), ID Oreščanin-Dušić, Zorana (Author), ID Bresjanac, Mara (Author), ID Blagojević, Duško (Author)

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Abstract
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.

Language:English
Keywords:noribogaine, erythrocytes, liver, kidney, glycogen, redox imbalance, catalase, xanthine oxidase, lipid peroxidation, thiols
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2022
Number of pages:18 str.
Numbering:Vol. 12, iss. 1, art. 16
PID:20.500.12556/RUL-136896 This link opens in a new window
UDC:616-092
ISSN on article:2075-1729
DOI:10.3390/life12010016 This link opens in a new window
COBISS.SI-ID:96210947 This link opens in a new window
Publication date in RUL:24.05.2022
Views:553
Downloads:86
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Record is a part of a journal

Title:Life
Shortened title:Life
Publisher:MDPI
ISSN:2075-1729
COBISS.SI-ID:519982617 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.01.2022

Secondary language

Language:Slovenian
Keywords:noribogain, eritrociti, jetra

Projects

Funder:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Project number:451-03-68/2020-14/200007

Funder:ARRS - Slovenian Research Agency
Project number:P3-0171
Name:Plastičnost živčevja v fizioloških in patofizioloških razmerah

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