20.500.12556/RUL-136896 Ibogaine has sex-specific plasma bioavailability, histopathological and redox/antioxidant effects in rat liver and kidneys a study on females Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent. noribogaine erythrocytes liver kidney glycogen redox imbalance catalase xanthine oxidase lipid peroxidation thiols noribogain eritrociti jetra true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-24 09:11:17 2022-05-24 09:11:22 2022-09-15 04:14:24 0000-00-00 00:00:00 2022 0 0 18 str. iss. 1, art. 16 Vol. 12 Jan. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 2075-1729 10.3390/life12010016 96210947 RAZ_Tatalovic_Nikola_2022.pdf RAZ_Tatalovic_Nikola_2022.pdf 1 D602B754016F7230AE5E1708D8CE1539 e387ea09ab23bebd0d3f1ecffada04a179138f6ff7f1aa378dcb29babfef639a 97cfd519-db30-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156694 https://www.mdpi.com/2075-1729/12/1/16 0 c034fdc4-db30-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156695 Medicinska fakulteta 0 0 0