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Lipoprotein(a)—the crossroads of atherosclerosis, atherothrombosis and inflammation
ID
Ugovšek, Sabina
(
Avtor
),
ID
Šebeštjen, Miran
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,86 MB)
MD5: 007DD2B2772B1C0E46003B1E1F7B880D
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2218-273X/12/1/26
Galerija slik
Izvleček
Increased lipoprotein(a) (Lp(a)) levels are an independent predictor of coronary artery disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD and DAS. Lp(a) levels are genetically determinated in an autosomal dominant mode, with great intra- and inter-ethnic diversity. Most variations in Lp(a) levels arise from genetic variations of the gene that encodes the apolipoprotein(a) component of Lp(a), the LPA gene. LPA is located on the long arm of chromosome 6, within region 6q2.6–2.7. Lp(a) levels increase cardiovascular risk through several unrelated mechanisms. Lp(a) quantitatively carries all of the atherogenic risk of low-density lipoprotein cholesterol, although it is even more prone to oxidation and penetration through endothelia to promote the production of foam cells. The thrombogenic properties of Lp(a) result from the homology between apolipoprotein(a) and plasminogen, which compete for the same binding sites on endothelial cells to inhibit fibrinolysis and promote intravascular thrombosis. LPA has up to 70% homology with the human plasminogen gene. Oxidized phospholipids promote differentiation of pro-inflammatory macrophages that secrete pro-inflammatory cytokines (e. g., interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α). The aim of this review is to define which of these mechanisms of Lp(a) is predominant in different groups of patients.
Jezik:
Angleški jezik
Ključne besede:
lipoprotein(a)
,
atherothrombosis
,
inflammation
,
coagulation
,
fibrinolysis
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
14 str.
Številčenje:
Vol. 12, iss. 1, art. 26
PID:
20.500.12556/RUL-136812
UDK:
612.115+616.13-004.6
ISSN pri članku:
2218-273X
DOI:
10.3390/biom12010026
COBISS.SI-ID:
91854339
Datum objave v RUL:
23.05.2022
Število ogledov:
503
Število prenosov:
79
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Objavi na:
Gradivo je del revije
Naslov:
Biomolecules
Skrajšan naslov:
Biomolecules
Založnik:
MDPI
ISSN:
2218-273X
COBISS.SI-ID:
519952921
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.01.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
lipoprotein(a)
,
aterotromboza
,
koagulacija
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