New insights into the role of cysteine cathepsins in neuroinflammation

Pišlar, Anja (avtor), Bolčina, Lara (avtor), Kos, Janko (avtor)

Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins, particularly during the early stage of neuroinflammation. This trigger signaling cascade that aggravate neurodegeneration. To date, most research on neuroinflammation has focused on the role of cysteine cathepsins, the largest cathepsin family. Cysteine cathepsins are primarily responsible for protein degradation in lysosomes; however, they also play a role in regulating a number of other important physiological and pathological processes. This review focuses on the functional roles of cysteine cathepsins in the central nervous system during neuroinflammation, with an emphasis on their roles in the polarization of microglia and neuroinflammation signaling, which in turn causes neuronal death and thus neurodegeneration.

• Jezik: Angleški jezik
• Ključne besede: microglia, cysteine cathepsins, neurotoxic polarization, neuroinflammation, neurodegeneration
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 21 str.
• Številčenje: Vol. 11, iss. 12, art. 1796
• PID: 20.500.12556/RUL-136698
• UDK: 577.152.34:616.831-003.8
• ISSN pri članku: 2218-273X
• DOI: 10.3390/biom11121796
• COBISS.SI-ID: 87903491
• Datum objave v RUL: 16.05.2022

Gradivo je del revije

• Naslov: Biomolecules
• Skrajšan naslov: Biomolecules
• Založnik: MDPI
• ISSN: 2218-273X
• COBISS.SI-ID: 519952921

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.12.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: mikroglija, cisteinski katepsini, nevrotoksična polarizacija, nevrovnetje, nevrodegeneracija, katepsini, nevrodegenerativne bolezni