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MicroRNAs in leukemias : a clinically annotated compendium
ID
Turk, Aleksander
(
Avtor
),
ID
Calin, George Adrian
(
Avtor
),
ID
Kunej, Tanja
(
Avtor
)
PDF - Predstavitvena datoteka,
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(2,87 MB)
MD5: A9BC16CF67644BBC6D52E41798081E17
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/23/7/3469
Galerija slik
Izvleček
Leukemias are a group of malignancies of the blood and bone marrow. Multiple types of leukemia are known, however reliable treatments have not been developed for most leukemia types. Furthermore, even relatively reliable treatments can result in relapses. MicroRNAs (miRNAs) are a class of short, noncoding RNAs responsible for epigenetic regulation of gene expression and have been proposed as a source of potential novel therapeutic targets for leukemias. In order to identify central miRNAs for leukemia, we conducted data synthesis using two databases: miRTarBase and DISNOR. A total of 137 unique miRNAs associated with 16 types of leukemia were retrieved from miRTarBase and 86 protein-coding genes associated with leukemia were retrieved from the DISNOR database. Based on these data, we formed a visual network of 248 miRNA-target interactions (MTI) between leukemia-associated genes and miRNAs associated with ≥4 leukemia types. We then manually reviewed the literature describing these 248 MTIs for interactions identified in leukemia studies. This manually curated data was then used to visualize a network of 64 MTIs identified in leukemia patients, cell lines and animal models. We also formed a visual network of miRNA-leukemia associations. Finally, we compiled leukemia clinical trials from the ClinicalTrials database. miRNAs with the highest number of MTIs were miR-125b-5p, miR-155-5p, miR-181a-5p and miR-19a-3p, while target genes with the highest number of MTIs were TP53, BCL2, KIT, ATM, RUNX1 and ABL1. The analysis of 248 MTIs revealed a large, highly interconnected network. Additionally, a large MTI subnetwork was present in the network visualized from manually reviewed data. The interconnectedness of the MTI subnetwork suggests that certain miRNAs represent central disease molecules for multiple leukemia types. Additional studies on miRNAs, their target genes and associated biological pathways are required to elucidate the therapeutic potential of miRNAs in leukemia.
Jezik:
Angleški jezik
Ključne besede:
microRNA (miRNA)
,
leukemia
,
interaction network
,
miRNA-target interaction (MTI)
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
16 str.
Številčenje:
Vol. 23, iss. 7, art. 3469
PID:
20.500.12556/RUL-136354
UDK:
575:616
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms23073469
COBISS.SI-ID:
102046467
Datum objave v RUL:
25.04.2022
Število ogledov:
628
Število prenosov:
101
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.04.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
genetika
,
mikro RNA
,
medicina
,
levkemija
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0326
Naslov:
Ginekologija in reprodukcija: genomika za personalizirano medicino
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