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Neuroendocrine carcinoma of the larynx and pharynx : a clinical and histopathological study
ID
Strojan, Primož
(
Avtor
),
ID
Šifrer, Robert
(
Avtor
),
ID
Ferlito, Alfio
(
Avtor
),
ID
Grašič-Kuhar, Cvetka
(
Avtor
),
ID
Lanišnik, Boštjan
(
Avtor
),
ID
Plavc, Gaber
(
Avtor
),
ID
Zidar, Nina
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,96 MB)
MD5: 2B0AE7E6140398A85642C4AB7B1317C6
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2072-6694/13/19/4813
Galerija slik
Izvleček
Neuroendocrine carcinomas (NECs) of the head and neck are rare and the experience scanty. The Cancer Registry of Slovenia database was used to identify cases of laryngeal and pharyngeal NECs diagnosed between 1995–2020. Biopsies were analyzed for the expression of standard neuroendocrine markers (synaptophysin, chromogranin, CD56), INSM1, Ki-67, p16, and PD-L1 (using the combined positive score, CPS). In situ hybridization for human papillomavirus (HPV) and Epstein–Barr virus (EBV) was performed. Twenty patients (larynx, 12; pharynx, 8) were identified. One tumor was well differentiated (WD), five were moderately differentiated (MD), and 14 were poorly differentiated (PD). Disease control was achieved solely by surgery in 4/4 MD/PD T1-2N0-1 tumors. Eight patients died of the disease, seven of which were due to distant metastases. All three traditional markers were positive in 11/17 NECs and the INSM1 marker in all 20 tumors. Two of fourteen p16-positive tumors were HPV-positive, but all three nasopharyngeal NECs were EBV-negative. Three tumors had CPSs ≥ 1. In conclusion, INSM1 was confirmed to be a reliable marker of neuroendocrine differentiation. Except in WD and early-stage MD/PD tumors, aggressive multimodal therapy is needed; the optimal systemic therapy remains to be determined. p16, HPV, and EBV seem to bear no prognostic information.
Jezik:
Angleški jezik
Ključne besede:
electrochemotherapy
,
head and neck cancer
,
neuroendocrine carcinoma
,
diagnosis
,
therapy
,
prognosis
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
16 str.
Številčenje:
Vol. 13, iss. 19, art. 4813
PID:
20.500.12556/RUL-136299
UDK:
615.82/.84
ISSN pri članku:
2072-6694
DOI:
10.3390/cancers13194813
COBISS.SI-ID:
79949315
Datum objave v RUL:
22.04.2022
Število ogledov:
699
Število prenosov:
95
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Cancers
Skrajšan naslov:
Cancers
Založnik:
MDPI
ISSN:
2072-6694
COBISS.SI-ID:
517914137
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.10.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
elektrokemoterapija
,
rak glave in vratu
,
nevroendokrini rak
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0307
Naslov:
Rak glave in vratu - analiza bioloških značilnosti in poskus izboljšanja zdravljenja
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0054
Naslov:
Patologija in molekularna genetika
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